The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: June 2015

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1. Nanoparticulate STING agonists are potent lymph node-targeted vaccine adjuvants. Hanson MC, Crespo MP, Abraham W, Moynihan KD, Szeto GL, Chen SH, Melo MB, Mueller S, Irvine DJ. J Clin Investpubmed:25938786;  doi:10.1172/JCI79915

2. Endothelial thermotolerance impairs nanoparticle transport in tumors. Bagley AF, Scherz-Shouval R, Galie PA, Zhang AQ, Wyckoff J, Whitesell L, Chen CS, Lindquist S, Bhatia SN. Cancer Respubmed:26122846;  doi:10.1158/0008-5472.CAN-15-0325

3. H nuclear magnetic resonance (NMR) as a tool to measure dehydration in mice. Li M, Vassiliou CC, Colucci LA, Cima MJ. NMR Biomed.pubmed:26123278;  doi:10.1002/nbm.3334

4. Covalent modification of synthetic hydrogels with bioactive proteins via sortase-mediated ligation. Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG. Biomacromoleculespubmed:26098148;  doi:10.1021/acs.biomac.5b00549

5. Human Vascular Tissue Models Formed from Human Induced Pluripotent Stem Cell Derived Endothelial Cells. Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL. Stem Cell Revpubmed:25190668;  doi:10.1007/s12015-014-9549-5

6. Influence of pH and Surface Chemistry on Poly-L-Lysine Adsorption onto Solid Supports Investigated by Quartz Crystal Microbalance with Dissipation Monitoring. Choi JH, Kim SO, Linardy E, Dreaden EC, Zhdanov VP, Hammond PT, Cho NJ. J Phys Chem B.pubmed:26061703;  doi:10.1021/acs.jpcb.5b01553

7. Spray Layer-by-Layer Assembled Clay Composite Thin Films as Selective Layers in Reverse Osmosis Membranes. Kovacs JR, Liu C, Hammond PT.ACS Appl Mater Interfacespubmed:26058008;  doi:10.1021/acsami.5b01879

8. Tumor-Targeted Synergistic Blockade of MAPK and PI3K From a Layer-by-Layer Nanoparticle. Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT. Clin Cancer Respubmed:26034127;  doi:10.1158/1078-0432.CCR-15-0013

9. Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes. Atukorale PU, Yang YS, Bekdemir A, Carney RP, Silva PJ, Watson N, Stellacci F, Irvine DJ. Nanoscalepubmed:26077112;  doi:10.1039/c5nr01355k

10. Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells. Huang B, Abraham WD, Zheng Y, Bustamante Lopez SC, Luo SS, Irvine DJ. Sci Transl Medpubmed:26062846;  doi:10.1126/scitranslmed.aaa5447

11. Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells. Arnold KB, Burgener A, Birse K, Romas L, Dunphy LJ, Shahabi K, Abou M, Westmacott GR, McCorrister S, Kwatampora J, Nyanga B, Kimani J, Masson L, Liebenberg LJ, Abdool Karim SS, Passmore JS, Lauffenburger DA, Kaul R, McKinnon LR.Mucosal Immunolpubmed:26104913;  doi:10.1038/mi.2015.51

12. Molecular signatures of immune activation and epithelial barrier remodeling are enhanced during the luteal phase of the menstrual cycle: implications for HIV susceptibility. Birse K, Arnold KB, Novak RM, McCorrister S, Shaw S, Westmacott GR, Ball TB, Lauffenburger DA, Burgener A. J Virolpubmed:26085144;  doi:10.1128/JVI.00756-15

13. Antibody-mediated Neutralization of Perfringolysin O for Intracellular Protein Delivery. Yang NJ, Liu DV, Sklaviadis D, Gui DY, Vander Heiden MG, Wittrup KD. Mol Pharmpubmed:25881713;  doi:10.1021/mp500797n

14. Accelerating the Translation of Nanomaterials in Biomedicine. Mitragotri S, Anderson DG, Chen X, Chow EK, Ho D, Kabanov AV, Karp JM, Kataoka K, Mirkin CA, Petrosko SH, Shi J, Stevens MM, Sun S, Teoh S, Venkatraman SS, Xia Y, Wang S, Gu Z, Xu C. ACS Nano.pubmed:26115196;  doi:10.1021/acsnano.5b03569

15. Adenovirus-mediated somatic genome editing of Pten by CRISPR/Cas9 in mouse liver in spite of Cas9-specific immune responses. Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer E, Weng Z, Gao G, Xue W. Hum Gene Ther.pubmed:26086867;  doi:10.1089/hum.2015.087

16. Silencing of CCR2 in myocarditis. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Eur Heart Jpubmed:24950695;  doi:10.1093/eurheartj/ehu225

17. Biodegradable nano-films for capture and non-invasive release of circulating tumor cells. Li W, Reategui E, Park MH, Castleberry S, Deng JZ, Hsu B, Mayner S, Jensen AE, Sequist LV, Maheswaran S, Haber DA, Toner M, Stott SL, Hammond PT. Biomaterials.pubmed:26142780;  doi:10.1016/j.biomaterials.2015.06.036

18. Adsorption of hyaluronic acid on solid supports: Role of pH and surface chemistry in thin film self-assembly. Choi JH, Kim SO, Linardy E, Dreaden EC, Zhdanov VP, Hammond PT, Cho NJ. J Colloid Interface Scipubmed:25734222;  doi:10.1016/j.jcis.2015.01.060

19. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. Science.pubmed:26089520;  doi:10.1126/science.aaa8205

20. Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules. O'Shea TM, Webber MJ, Aimetti AA, Langer R. Adv Healthc Materpubmed:26088467;  doi:10.1002/adhm.201500334

21. Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Celiz AD, Smith JG, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR. Adv Materpubmed:26033422;  doi:10.1002/adma.201501351

22. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Lock J, Aresta-Dasilva S, Bochenek M, Mendoza-Elias J, Wang Y, Qi M, Lavin DM, Chen M, Dholakia N, Thakrar R, Lacik I, Weir GC, Oberholzer J, Greiner DL, Langer R, Anderson DG. Nat Materpubmed:25985456;  doi:10.1038/nmat4290

23. Dendrimeric siRNA for Efficient Gene Silencing. Hong CA, Eltoukhy AA, Lee H, Langer R, Anderson DG, Nam YS. Angew Chem Int Ed Engl.pubmed:25892329;  doi:10.1002/anie.201412493

24. Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning. Ozkumur AY, Goods BA, Love JC. Small.pubmed:26121321;  doi:10.1002/smll.201500674

25. A perfusion-capable microfluidic bioreactor for assessing microbial heterologous protein production. Mozdzierz NJ, Love KR, Lee KS, Lee HL, Shah KA, Ram RJ, Love JC. Lab Chippubmed:26055071;  doi:10.1039/c5lc00443h

26. Accurate Predictions of Genetic Circuit Behavior from Part Characterization and Modular Composition. Davidsohn N, Beal J, Kiani S, Adler A, Yaman F, Li Y, Xie Z, Weiss R. ACS Synth Biolpubmed:25369267;  doi:10.1021/sb500263b

27. Photopatterned oil-reservoir micromodels with tailored wetting properties. Lee H, Lee SG, Doyle PS. Lab Chip.pubmed:26082065;  doi:10.1039/c5lc00277j

28. Stem Cell Research: Promise and Progress. Jaenisch R. Stem Cell Reportspubmed:26070609;  doi:10.1016/j.stemcr.2015.05.015

29. Antagonistic Regulation of mRNA Expression and Splicing by CELF and MBNL Proteins. Wang ET, Ward AJ, Cherone J, Wang TT, Giudice J, Treacy D, Freese P, Lambert NJ, Saxena T, Cooper TA, Burge CB. Genome Respubmed:25883322;  doi:10.1101/gr.184390.114

30. TET1 is a tumor suppressor of hematopoietic malignancy. Cimmino L, Dawlaty MM, Ndiaye-Lobry D, Yap YS, Bakogianni S, Yu Y, Bhattacharyya S, Shaknovich R, Geng H, Lobry C, Mullenders J, King B, Trimarchi T, Aranda-Orgilles B, Liu C, Shen S, Verma AK, Jaenisch R, Aifantis I. Nat Immunol.pubmed:25867473;  doi:10.1038/ni.3148

31. PPAR-alpha and glucocorticoid receptor synergize to promote erythroid progenitor self-renewal. Lee HY, Gao X, Barrasa MI, Li H, Elmes RR, Peters LL, Lodish HF. Naturepubmed:25970251;  doi:10.1038/nature14326

32. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, Jain R, Joseph I, Kim J, Kasaian K, Mikkelsen T, Murray BA, O'Neill BP, Pachter L, Parsons DW, Sougnez C, Sulman EP, Vandenberg SR, Van Meir EG, von Deimling A, Zhang H, Crain D, Lau K, Mallery D, Morris S, Paulauskis J, Penny R, Shelton T, Sherman M, Yena P, Black A, Bowen J, Dicostanzo K, Gastier-Foster J, Leraas KM, Lichtenberg TM, Pierson CR, Ramirez NC, Taylor C, Weaver S, Wise L, Zmuda E, Davidsen T, Demchok JA, Eley G, Ferguson ML, Hutter CM, Mills Shaw KR, Ozenberger BA, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Ayala B, Baboud J, Chudamani S, Jensen MA, Liu J, Pihl T, Raman R, Wan Y, Wu Y, Ally A, Auman JT, Balasundaram M, Balu S, Baylin SB, Beroukhim R, Bootwalla MS, Bowlby R, Bristow CA, Brooks D, Butterfield Y, Carlsen R, Carter S, Chin L, Chu A, Chuah E, Cibulskis K, Clarke A, Coetzee SG, Dhalla N, Fennell T, Fisher S, Gabriel S, Getz G, Gibbs R, Guin R, Hadjipanayis A, Hayes DN, Hinoue T, Hoadley K, Holt RA, Hoyle AP, Jefferys SR, Jones S, Jones CD, Kucherlapati R, Lai PH, Lander E, Lee S, Lichtenstein L, Ma Y, Maglinte DT, Mahadeshwar HS, Marra MA, Mayo M, Meng S, Meyerson ML, Mieczkowski PA, Moore RA, Mose LE, Mungall AJ, Pantazi A, Parfenov M, Park PJ, Parker JS, Perou CM, Protopopov A, Ren X, Roach J, Sabedot TS, Schein J, Schumacher SE, Seidman JG, Seth S, Shen H, Simons JV, Sipahimalani P, Soloway MG, Song X, Sun H, Tabak B, Tam A, Tan D, Tang J, Thiessen N, Triche TJr, Van Den Berg DJ, Veluvolu U, Waring S, Weisenberger DJ, Wilkerson MD, Wong T, Wu J, Xi L, Xu AW, Yang L, Zack TI, Zhang J, Aksoy BA, Arachchi H, Benz C, Bernard B, Carlin D, Cho J, DiCara D, Frazer S, Fuller GN, Gao J, Gehlenborg N, Haussler D, Heiman DI, Iype L, Jacobsen A, Ju Z, Katzman S, Kim H, Knijnenburg T, Kreisberg RB, Lawrence MS, Lee W, Leinonen K, Lin P, Ling S, Liu W, Liu Y, Liu Y, Lu Y, Mills G, Ng S, Noble MS, Paull E, Rao A, Reynolds S, Saksena G, Sanborn Z, Sander C, Schultz N, Senbabaoglu Y, Shen R, Shmulevich I, Sinha R, Stuart J, Sumer SO, Sun Y, Tasman N, Taylor BS, Voet D, Weinhold N, Weinstein JN, Yang D, Yoshihara K, Zheng S, Zhang W, Zou L, Abel T, Sadeghi S, Cohen ML, Eschbacher J, Hattab EM, Raghunathan A, Schniederjan MJ, Aziz D, Barnett G, Barrett W, Bigner DD, Boice L, Brewer C, Calatozzolo C, Campos B, Carlotti CGJr, Chan TA, Cuppini L, Curley E, Cuzzubbo S, Devine K, DiMeco F, Duell R, Elder JB, Fehrenbach A, Finocchiaro G, Friedman W, Fulop J, Gardner J, Hermes B, Herold-Mende C, Jungk C, Kendler A, Lehman NL, Lipp E, Liu O, Mandt R, McGraw M, Mclendon R, McPherson C, Neder L, Nguyen P, Noss A, Nunziata R, Ostrom QT, Palmer C, Perin A, Pollo B, Potapov A, Potapova O, Rathmell WK, Rotin D, Scarpace L, Schilero C, Senecal K, Shimmel K, Shurkhay V, Sifri S, Singh R, Sloan AE, Smolenski K, Staugaitis SM, Steele R, Thorne L, Tirapelli DP, Unterberg A, Vallurupalli M, Wang Y, Warnick R, Williams F, Wolinsky Y, Bell S, Rosenberg M, Stewart C, Huang F, Grimsby JL, Radenbaugh AJ, Zhang J.N Engl J Medpubmed:26061751;  doi:10.1056/NEJMoa1402121

33. Toward stem cell-based phenotypic screens for neurodegenerative diseases. Khurana V, Tardiff DF, Chung CY, Lindquist S. Nat Rev Neurol.pubmed:25986505;  doi:10.1038/nrneurol.2015.79

34. Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair. Alexander JL, Barrasa MI, Orr-Weaver TL. Curr Biolpubmed:26051888;  doi:10.1016/j.cub.2015.04.058

35. Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein. Nordman JT, Orr-Weaver TL. Bioessayspubmed:26059810;  doi:10.1002/bies.201500021

36. Variations in sister chromatid cohesion dysfunction in esco2 mutant zebrafish reflects the phenotypic diversity of Roberts Syndrome. Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM. Dis Model Mechpubmed:26044958;  doi:10.1242/dmm.019059

37. When bigger is better: the role of polyploidy in organogenesis. Orr-Weaver TL. Trends Genetpubmed:25921783;  doi:10.1016/j.tig.2015.03.011

38. Cell biology: The micronucleus gets its big break. Knouse KA, Amon A. Naturepubmed:26017308;  doi:10.1038/nature14528

39. RNA Regulation by Poly(ADP-Ribose) Polymerases. Bock FJ, Todorova TT, Chang P. Mol Cellpubmed:26091344;  doi:10.1016/j.molcel.2015.01.037

40. Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer. Todorova T, Bock FJ, Chang P. Trends Mol Med.pubmed:25851173;  doi:10.1016/j.molmed.2015.03.002