The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: April 2015

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1. Klaus Mosbach tribute. Clark DS, Karube I, Sode K, Bulow L, Bruggemann O, Lowe CR, Poulsen PB, Langer RS. Biotechnol Bioeng.pubmed:25599981;  doi:10.1002/bit.25507

2. The In Vivo Compatibility of Graphene Oxide with Differing Oxidation States. Sydlik SA, Jhunjhunwala S, Webber MJ, Anderson DG, Langer R. ACS Nanopubmed:25849074;  doi:10.1021/acsnano.5b01290

3. Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity. Sanni O, Chang CY, Anderson DG, Langer R, Davies MC, Williams PM, Williams P, Alexander MR, Hook AL. Adv Healthc Materpubmed:25491266;  doi:10.1002/adhm.201400648

4. Phosphotyrosine signaling analysis in human tumors is confounded by systemic Ischemia-driven artifacts and intra-specimen heterogeneity. Gajadhar AS, Johnson H, Slebos RJ, Shaddox K, Wiles K, Washington MK, Herline AJ, Levine DA, Liebler DC, White FM. Cancer Res.pubmed:25670172;  doi:10.1158/0008-5472.CAN-14-2309

5. Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering. Stevens KR, Miller JS, Blakely BL, Chen CS, Bhatia SN. J Biomed Mater Res Apubmed:25851120;  doi:10.1002/jbm.a.35478

6. Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Tzafriri AR, Keating JH, Markham PM, Spognardi AM, L Stanley JR, Wong G, Zani BG, Highsmith D, O'Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Sci Transl Med.pubmed:25925684;  doi:10.1126/scitranslmed.aaa3236

7. Photopatterning of Hydrogel Scaffolds Coupled to Filter Materials Using Stereolithography for Perfused 3D Culture of Hepatocytes. Neiman JA, Raman R, Chan V, Rhoads MG, Raredon MS, Velazquez JJ, Dyer RL, Bashir R, Hammond PT, Griffith LG. Biotechnol Bioeng.pubmed:25384798;  doi:10.1002/bit.25494

8. Ultrahigh speed en face OCT capsule for endoscopic imaging. Liang K, Traverso G, Lee HC, Ahsen OO, Wang Z, Potsaid B, Giacomelli M, Jayaraman V, Barman R, Cable A, Mashimo H, Langer R, Fujimoto JG. Biomed Opt Expresspubmed:25909001;  doi:10.1364/BOE.6.001146

9. An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors. Jonas O, Landry HM, Fuller JE, Santini JTJr, Baselga J, Tepper RI, Cima MJ, Langer R. Sci Transl Medpubmed:25904741;  doi:10.1126/scitranslmed.3010564

10. Stretching self-entangled DNA molecules in elongational fields. Renner CB, Doyle PS. Soft Matterpubmed:25693945;  doi:10.1039/c4sm02738h

11. Highly efficient Cas9-mediated transcriptional programming. Chavez A, Scheiman J, Vora S, Pruitt BW, Tuttle M, P R Iyer E, Lin S, Kiani S, Guzman CD, Wiegand DJ, Ter-Ovanesyan D, Braff JL, Davidsohn N, Housden BE, Perrimon N, Weiss R, Aach J, Collins JJ, Church GM. Nat Methods.pubmed:25730490;  doi:10.1038/nmeth.3312

12. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. J Exp Medpubmed:25800955;  doi:10.1084/jem.20141642

13. Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2. Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Cancer Cellpubmed:25873172;  doi:10.1016/j.ccell.2015.03.004

14. Dissecting risk haplotypes in sporadic Alzheimer's disease. Soldner F, Jaenisch R. Cell Stem Cellpubmed:25842969;  doi:10.1016/j.stem.2015.03.010

15. HypE-specific Nanobodies as Tools to modulate HypE-mediated Target AMPylation. Truttmann MC, Wu Q, Stiegeler S, Duarte JN, Ingram J, Ploegh HL. J Biol Chempubmed:25678711;  doi:10.1074/jbc.M114.634287

16. Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers. Hnisz D, Schuijers J, Lin CY, Weintraub AS, Abraham BJ, Lee TI, Bradner JE, Young RA. Mol Cellpubmed:25801169;  doi:10.1016/j.molcel.2015.02.014

17. In vivo genome editing using Staphylococcus aureus Cas9. Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. Naturepubmed:25830891;  doi:10.1038/nature14299

18. Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast. Blank HM, Sheltzer JM, Meehl CM, Amon A. Mol Biol Cellpubmed:25694455;  doi:10.1091/mbc.E14-10-1442

19. The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung. Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E. J Thorac Oncol.pubmed:25675280;  doi:10.1097/JTO.0000000000000459

20. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. Naturepubmed:25855294;  doi:10.1038/nature14363

21. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness. Katajisto P, Dohla J, Chaffer C, Pentinmikko N, Marjanovic N, Iqbal S, Zoncu R, Chen W, Weinberg RA, Sabatini DM. Sciencepubmed:25837514;  doi:10.1126/science.1260384

22. Single-Molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading. Ticau S, Friedman LJ, Ivica NA, Gelles J, Bell SP. Cellpubmed:25892223;  doi:10.1016/j.cell.2015.03.012

23. Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovacs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabasi AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJ, Lindquist S, Vidal M. Cellpubmed:25910212;  doi:10.1016/j.cell.2015.04.013

24. Perturbation-Expression Analysis Identifies RUNX1 as a Regulator of Human Mammary Stem Cell Differentiation. Sokol ES, Sanduja S, Jin DX, Miller DH, Mathis RA, Gupta PB. PLoS Comput Biolpubmed:25894653;  doi:10.1371/journal.pcbi.1004161

25. A DNA/HDAC dual-targeting drug CY190602 with significantly enhanced anticancer potency. Liu C, Ding H, Li X, Pallasch CP, Hong L, Guo D, Chen Y, Wang D, Wang W, Wang Y, Hemann MT, Jiang H. EMBO Mol Medpubmed:25759362;  doi:10.15252/emmm.201404580

26. Macrophage Activation: On PAR with LPS. Bock FJ, Chang P. Chem Biolpubmed:25910238;  doi:10.1016/j.chembiol.2015.04.006

27. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. J Biomol Screenpubmed:25918037;  doi:10.1177/1087057115583037

28. Reproducibility in science. Yaffe MB. Sci Signalpubmed:25852185;  doi:10.1126/scisignal.aaa5764

29. Criteria for biological reproducibility: What does "n" mean? Naegle K, Gough NR, Yaffe MB. Sci Signal.pubmed:25852186;  doi:10.1126/scisignal.aab1125