The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: March 2015

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1. Evaluation of an intramedullary bone stabilization system using a light-curable monomer in sheep. Zani BG, Baird R, Stanley JR, Markham PM, Wilke M, Zeiter S, Beck A, Nehrbass D, Kopia GA, Edelman ER, Rabiner R. J Biomed Mater Res B Appl Biomaterpubmed:25772144;  doi:10.1002/jbm.b.33380

2. Tunable Nanostructured Coating for the Capture and Selective Release of Viable Circulating Tumor Cells. Reategui E, Aceto N, Lim EJ, Sullivan JP, Jensen AE, Zeinali M, Martel JM, Aranyosi AJ, Li W, Castleberry S, Bardia A, Sequist LV, Haber DA, Maheswaran S, Hammond PT, Toner M, Stott SL. Adv Materpubmed:25640006;  doi:10.1002/adma.201404677

3. Human iPSC-Derived Hepatocyte-like Cells Support Plasmodium Liver-Stage Infection In Vitro. Ng S, Schwartz RE, March S, Galstian A, Gural N, Shan J, Prabhu M, Mota MM, Bhatia SN. Stem Cell Reportspubmed:25660406;  doi:10.1016/j.stemcr.2015.01.002

4. Enhancing physiologic simulations using supervised learning on coarse mesh solutions. Kolandaivelu K, O'Brien CC, Shazly T, Edelman ER, Kolachalama VB. J R Soc Interfacepubmed:25652458;  doi:10.1098/rsif.2014.1073

5. Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs. Schoellhammer CM, Srinivasan S, Barman R, Mo SH, Polat BE, Langer R, Blankschtein D. J Control Releasepubmed:25662228;  doi:10.1016/j.jconrel.2015.02.002

6. HDL-Mimetic PLGA Nanoparticle To Target Atherosclerosis Plaque Macrophages. Sanchez-Gaytan BL, Fay F, Lobatto ME, Tang J, Ouimet M, Kim Y, van der Staay SE, van Rijs SM, Priem B, Zhang L, Fisher EA, Moore KJ, Langer R, Fayad ZA, Mulder WJ. Bioconjug Chem.pubmed:25650634;  doi:10.1021/bc500517k

7. Non-Cell-Adhesive Substrates for Printing of Arrayed Biomaterials. Appel EA, Larson BL, Luly KM, Kim JD, Langer R. Adv Healthc Mater.pubmed:25430948;  doi:10.1002/adhm.201400594

8. A Perspective on the Clinical Translation of Scaffolds for Tissue Engineering. Webber MJ, Khan OF, Sydlik SA, Tang BC, Langer R. Ann Biomed Eng.pubmed:25201605;  doi:10.1007/s10439-014-1104-7

9. Influenza Surveillance: 2014-2015 H1N1 "Swine"-Derived Influenza Viruses from India. Tharakaraman K, Sasisekharan R. Cell Host Microbe.pubmed:25766285;  doi:10.1016/j.chom.2015.02.019

10. Dabigatran and Rivaroxaban Use in Atrial Fibrillation Patients on Hemodialysis. Chan KE, Edelman ER, Wenger JB, Thadhani RI, Maddux FW.Circulationpubmed:25595139;  doi:10.1161/CIRCULATIONAHA.114.014113

11. Modular construction of mammalian gene circuits using TALE transcriptional repressors. Li Y, Jiang Y, Chen H, Liao W, Li Z, Weiss R, Xie Z. Nat Chem Biolpubmed:25643171;  doi:10.1038/nchembio.1736

12. Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution. Tzeng A, Kwan BH, Opel CF, Navaratna T, Wittrup KD. Proc Natl Acad Sci U S Apubmed:25733854;  doi:10.1073/pnas.1416159112

13. Perspective: Special delivery for the gut. Traverso G, Langer R. Naturepubmed:25806494;  doi:10.1038/519S19a

14. Particulates from hydrophilic-coated guiding sheaths embolise to the brain. Stanley JR, Tzafriri AR, Regan K, LaRochelle A, Wong G, Zani BG, Markham PM, Bailey L, Spognardi A, Kopia GA, Edelman ER. EuroInterventionpubmed:25735934;  doi:10.4244/EIJY15M03_02

15. Origins and Impacts of New Mammalian Exons. Merkin JJ, Chen P, Alexis MS, Hautaniemi SK, Burge CB. Cell Rep.pubmed:25801031;  doi:10.1016/j.celrep.2015.02.058

16. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG. Genome Respubmed:25650244;  doi:10.1101/gr.180612.114

17. Site-specific protein modification using immobilized sortase in batch and continuous-flow systems. Witte MD, Wu T, Guimaraes CP, Theile CS, Blom AE, Ingram JR, Li Z, Kundrat L, Goldberg SD, Ploegh HL. Nat Protocpubmed:25719269;  doi:10.1038/nprot.2015.026

18. Accommodating family life: mentoring future female faculty members. Lodish HF. Trends Cell Biolpubmed:25601644;  doi:10.1016/j.tcb.2014.12.007

19. Licensing of Primordial Germ Cells for Gametogenesis Depends on Genital Ridge Signaling. Hu YC, Nicholls PK, Soh YQ, Daniele JR, Junker JP, van Oudenaarden A, Page DC. PLoS Genetpubmed:25739037;  doi:10.1371/journal.pgen.1005019

20. Long non-coding RNAs as regulators of the endocrine system. Knoll M, Lodish HF, Sun L. Nat Rev Endocrinol.pubmed:25560704;  doi:10.1038/nrendo.2014.229

21. Intracellular expression of camelid single domain antibodies specific for influenza virus nucleoprotein (NP) uncovers distinct features of its nuclear localization. Ashour J, Schmidt F, Hanke L, Cragnolini J, Cavallari M, Altenburg A, Brewer R, Ingram J, Shoemaker C, Ploegh H. J Virol.pubmed:25540369;  doi:10.1128/JVI.02693-14

22. Cutting the Gordian Helix - Regulating Genomic Testing in the Era of Precision Medicine. Lander ES. N Engl J Med.pubmed:25689017;  doi:10.1056/NEJMp1501964

23. A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. Genes Dev.pubmed:25737277;  doi:10.1101/gad.254151.114

24. Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis. Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Cellpubmed:25748654;  doi:10.1016/j.cell.2015.02.038

25. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA. Proc Natl Acad Sci U S Apubmed:25755260;  doi:10.1073/pnas.1502971112

26. A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer. Wilson FH, Johannessen CM, Piccioni F, Tamayo P, Kim JW, Van Allen EM, Corsello SM, Capelletti M, Calles A, Butaney M, Sharifnia T, Gabriel SB, Mesirov JP, Hahn WC, Engelman JA, Meyerson M, Root DE, Janne PA, Garraway LA. Cancer Cellpubmed:25759024;  doi:10.1016/j.ccell.2015.02.005

27. Harnessing RNA interference for therapy: the silent treatment. Lieberman J, Sharp PA. JAMApubmed:25803342;  doi:10.1001/jama.2015.1241

28. Famine versus feast: understanding the metabolism of tumors in vivo. Mayers JR, Vander Heiden MG. Trends Biochem Sci.pubmed:25639751;  doi:10.1016/j.tibs.2015.01.004

29. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. Faber AC, Farago AF, Costa C, Dastur A, Gomez-Caraballo M, Robbins R, Wagner BL, Rideout WM3rd, Jakubik CT, Ham J, Edelman EJ, Ebi H, Yeo AT, Hata AN, Song Y, Patel NU, March RJ, Tam AT, Milano RJ, Boisvert JL, Hicks MA, Elmiligy S, Malstrom SE, Rivera MN, Harada H, Windle BE, Ramaswamy S, Benes CH, Jacks T, Engelman JA. Proc Natl Acad Sci U S Apubmed:25737542;  doi:10.1073/pnas.1411848112

30. Nutrient-Sensing Mechanisms across Evolution. Chantranupong L, Wolfson RL, Sabatini DM. Cellpubmed:25815986;  doi:10.1016/j.cell.2015.02.041

31. Tonic Zinc Inhibits Spontaneous Neuronal Firing in Dorsal Cochlear Nucleus Principal Neurons by Enhancing Glycinergic Neurotransmission. Perez-Rosello T, Anderson CT, Ling C, Lippard SJ, Tzounopoulos T. Neurobiol Dispubmed:25796568;  doi:10.1016/j.nbd.2015.03.012

32. Necroptosis-Inducing Rhenium(V) Oxo Complexes. Suntharalingam K, Awuah SG, Bruno PM, Johnstone TC, Wang F, Lin W, Zheng YR, Page JE, Hemann MT, Lippard SJ. J Am Chem Socpubmed:25698398;  doi:10.1021/ja511978y

33. Third row transition metals for the treatment of cancer. Johnstone TC, Suntharalingam K, Lippard SJ. Philos Trans A Math Phys Eng Sci.pubmed:25666060;  doi:10.1098/rsta.2014.0185

34. Stress response: PARP1 911. Bock FJ, Chang P. Nat Chem Biolpubmed:25689334;  doi:10.1038/nchembio.1756

35. Reflecting on fifty years of progress for women in science. Hopkins N. DNA Cell Biolpubmed:25689304;  doi:10.1089/dna.2015.2803

36. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC. Sciencepubmed:25745166;  doi:10.1126/science.aaa5026