The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: January 2015

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Publications Citing Koch Institute Faculty Members

1. Dabigatran and Rivaroxaban Use in Atrial Fibrillation Patients on Hemodialysis. Chan KE, Edelman ER, Wenger JB, Thadhani RI, Maddux FW. Circulation.pubmed:25595139;  doi:10.1161/CIRCULATIONAHA.114.014113

2. In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Hanson KK, March S, Ng S, Bhatia S, Mota MM. Eukaryot Cell.pubmed:25416236;  doi:10.1128/EC.00166-14

3. Five birds, one stone: Neutralization of alpha-hemolysin and four bi-component leukocidins of Staphylococcus aureus with a single human monoclonal antibody. Rouha H, Badarau A, Visram ZC, Battles MB, Prinz B, Magyarics Z, Nagy G, Mirkina I, Stulik L, Zerbs M, Jagerhofer M, Maierhofer B, Teubenbacher A, Dolezilkova I, Gross K, Banerjee S, Zauner G, Malafa S, Zmajkovic J, Maier S, Mabry R, Krauland E, Wittrup KD, Gerngross TU, Nagy E. MAbspubmed:25523282;  doi:10.4161/19420862.2014.985132

4. Innovation and Insight in Integrative Biology. Lauffenburger DA. Integr Biol (Camb)pubmed:25500816;  doi:10.1039/c4ib90047b

5. Model-driven Engineering of Gene Expression from RNA Replicons. Beal J, Wagner TE, Kitada T, Azizgolshani O, Parker JM, Densmore D, Weiss R. ACS Synth Biol.pubmed:24877739;  doi:10.1021/sb500173f

6. Actin foci facilitate activation of the phospholipase C-gamma in primary T lymphocytes via the WASP pathway. Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Elifepubmed:25758716;  doi:10.7554/eLife.04953

7. ADAM8 as a drug target in pancreatic cancer. Schlomann U, Koller G, Conrad C, Ferdous T, Golfi P, Garcia AM, Hofling S, Parsons M, Costa P, Soper R, Bossard M, Hagemann T, Roshani R, Sewald N, Ketchem RR, Moss ML, Rasmussen FH, Miller MA, Lauffenburger DA, Tuveson DA, Nimsky C, Bartsch JW. Nat Communpubmed:25629724;  doi:10.1038/ncomms7175

8. MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications. Curran TG, Zhang Y, Ma DJ, Sarkaria JN, White FM. Nat Commun.pubmed:25581283;  doi:10.1038/ncomms6924

9. Engineered bromodomains to explore the acetylproteome. Bryson BD, Rosario AM, Gootenberg J, Yaffe MB, White FM. Proteomicspubmed:25641834;  doi:10.1002/pmic.201400401

10. Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine. Ishikawa K, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa K, Hajjar RJ. Circ Heart Failpubmed:25342737;  doi:10.1161/CIRCHEARTFAILURE.114.001711

11. Regulation of dendrimer/dextran material performance by altered tissue microenvironment in inflammation and neoplasia. Oliva N, Carcole M, Beckerman M, Seliktar S, Hayward A, Stanley J, Parry NM, Edelman ER, Artzi N. Sci Transl Medpubmed:25632035;  doi:10.1126/scitranslmed.aaa1616

12. Target-responsive DNA/RNA nanomaterials for microRNA sensing and inhibition: The jack-of-all-trades in cancer nanotheranostics?. Conde J, Edelman ER, Artzi N. Adv Drug Deliv Rev.pubmed:25220355;  doi:10.1016/j.addr.2014.09.003

13. Stochastic Particle Barcoding for Single-Cell Tracking and Multiparametric Analysis. Castellarnau M, Szeto GL, Su HW, Tokatlian T, Love JC, Irvine DJ, Voldman J. Small.pubmed:25180800;  doi:10.1002/smll.201401369

14. Spray-Assisted Layer-by-Layer assembly on hyaluronic acid scaffolds for skin tissue engineering. Monteiro IP, Shukla A, Marques AP, Reis RL, Hammond PT. J Biomed Mater Res A.pubmed:24659574;  doi:10.1002/jbm.a.35178

15. Self-assembled hydrogels utilizing polymer-nanoparticle interactions. Appel EA, Tibbitt MW, Webber MJ, Mattix BA, Veiseh O, Langer R. Nat Commun.pubmed:25695516;  doi:10.1038/ncomms7295

16. Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Maldonado RA, LaMothe RA, Ferrari JD, Zhang A, Rossi RJ, Kolte PN, Griset AP, O'Neil C, Altreuter DH, Browning E, Johnston L, Farokhzad OC, Langer R, Scott DW, von Andrian UH, Kishimoto TK. Proc Natl Acad Sci U S Apubmed:25548186;  doi:10.1073/pnas.1408686111

17. Managing diabetes with nanomedicine: challenges and opportunities. Veiseh O, Tang BC, Whitehead KA, Anderson DG, Langer R. Nat Rev Drug Discovpubmed:25430866;  doi:10.1038/nrd4477

18. Synthesis and Characterization of a Library of In-Situ Curing, Nonswelling Ethoxylated Polyol Thiol-ene Hydrogels for Tailorable Macromolecule Delivery. O'Shea TM, Aimetti AA, Kim E, Yesilyurt V, Langer R. Adv Materpubmed:25381960;  doi:10.1002/adma.201403724

19. Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Mol Cell.pubmed:25482511;  doi:10.1016/j.molcel.2014.10.027

20. Glycan array data management at consortium for functional glycomics. Venkataraman M, Sasisekharan R, Raman R. Methods Mol Biolpubmed:25753711;  doi:10.1007/978-1-4939-2343-4_13

21. Capillary electrophoretic analysis of isolated sulfated polysaccharides to characterize pharmaceutical products. Shriver Z, Sasisekharan R. Methods Mol Biolpubmed:25325952;  doi:10.1007/978-1-4939-1714-3_15

22. Nanotechnology. Langer R, Weissleder R. JAMApubmed:25585320;  doi:10.1001/jama.2014.16315

23. Metabolism, Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Sciencepubmed:25567906;  doi:10.1126/science.1257132

24. Nutrient-sensing mechanisms and pathways. Efeyan A, Comb WC, Sabatini DM. Naturepubmed:25592535;  doi:10.1038/nature14190

25. Methane monooxygenase: functionalizing methane at iron and copper. Sazinsky MH, Lippard SJ. Met Ions Life Scipubmed:25707469;  doi:10.1007/978-3-319-12415-5_6

26. How does multistep tumorigenesis really proceed?. Chaffer CL, Weinberg RA. Cancer Discovpubmed:25583800;  doi:10.1158/2159-8290.CD-14-0788

27. Synthesis and Characterization of Mononuclear, Pseudotetrahedral Cobalt(III) Compounds. Kozhukh J, Minier MA, Lippard SJ. Inorg Chempubmed:25531129;  doi:10.1021/ic5009279

28. Improvements in the Synthesis and Understanding of the Iodo-bridged Intermediate en Route to the Pt(IV) Prodrug Satraplatin. Johnstone TC, Lippard SJ. Inorganica Chim Acta.pubmed:25435590;  doi:10.1016/j.ica.2014.08.047

29. Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(iv) prodrugs. Johnstone TC, Alexander SM, Wilson JJ, Lippard SJ. Dalton Transpubmed:25367395;  doi:10.1039/c4dt02627f

30. Origin of metastable knots in single flexible chains. Dai L, Renner CB, Doyle PS. Phys Rev Lettpubmed:25659023;  

31. Directed evolution of APEX2 for electron microscopy and proximity labeling. Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY. Nat Methods.pubmed:25419960;  doi:10.1038/nmeth.3179