The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: March 2014

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Publications Citing Koch Institute Faculty Members

1. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Proc Natl Acad Sci U S A. pubmed:24516150;  doi:10.1073/pnas.1322937111

2. Structure-based programming of lymph-node targeting in molecular vaccines. Liu H, Moynihan KD, Zheng Y, Szeto GL, Li AV, Huang B, Van Egeren DS, Park C, Irvine DJ. Nature. pubmed:24531764;  doi:10.1038/nature12978

3. Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. Warren AD, Kwong GA, Wood DK, Lin KY, Bhatia SN. Proc Natl Acad Sci U S A. pubmed:24567404;  doi:10.1073/pnas.1314651111

4. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Vaccine. pubmed:24593999;  doi:10.1016/j.vaccine.2014.02.027

5. Profiling human antibody responses by integrated single-cell analysis. Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC. Vaccine. pubmed:24602776;  doi:10.1016/j.vaccine.2014.02.020

6. Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo. Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG. Adv Healthc Mater. pubmed:24623658;  doi:10.1002/adhm.201400054

7. Bioreactor Technologies to Support Liver Function In Vitro. Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG. Adv Drug Deliv Rev. pubmed:24607703;  doi:10.1016/j.addr.2014.02.011

8. Engineering Liver. Griffith LG, Wells A, Stolz DB. Hepatology. pubmed:24668880;  doi:10.1002/hep.27150

9. Spray-Assisted Layer-by-Layer assembly on hyaluronic acid scaffolds for skin tissue engineering. Monteiro IP, Shukla A, Marques AP, Reis RL, Hammond PT. J Biomed Mater Res A. pubmed:24659574;  doi:10.1002/jbm.a.35178

10. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Nat Biotechnol. pubmed:24681508;  doi:10.1038/nbt.2884

11. Assembly of a Bacteriophage-Based Template for the Organization of Materials into Nanoporous Networks. Courchesne NM, Klug MT, Chen PY, Kooi SE, Yun DS, Hong N, Fang NX, Belcher AM, Hammond PT. Adv Mater. pubmed:24648015;  doi:10.1002/adma.201305928

12. Stretchable Polymeric Multielectrode Array for Conformal Neural Interfacing. Guo L, Ma M, Zhang N, Langer R, Anderson DG. Adv Mater. pubmed:24150828;  doi:10.1002/adma.201304140

13. Microneedle Electrodes Toward an Amperometric Glucose-Sensing Smart Patch. Invernale MA, Tang BC, York RL, Le L, Hou DY, Anderson DG. Adv Healthc Mater. pubmed:24039157;  doi:10.1002/adhm.201300142

14. Tunable staged release of therapeutics from layer-by-layer coatings with clay interlayer barrier. Min J, Braatz RD, Hammond PT. Biomaterials. pubmed:24388389;  doi:10.1016/j.biomaterials.2013.12.009

15. Skin permeabilization for transdermal drug delivery: recent advances and future prospects. Schoellhammer CM, Blankschtein D, Langer R. Expert Opin Drug Deliv. pubmed:24392787;  doi:10.1517/17425247.2014.875528

16. Predicting response to endovascular therapies: Dissecting the roles of local lesion complexity, systemic comorbidity, and clinical uncertainty. Kolandaivelu K, Leiden BB, Edelman ER. J Biomech. pubmed:24495755;  doi:10.1016/j.jbiomech.2014.01.006

17. Tailoring Chimeric Ligands for Studying and Biasing ErbB Receptor Family Interactions. Krueger AT, Kroll C, Sanchez E, Griffith LG, Imperiali B. Angew Chem Int Ed Engl. pubmed:24481645;  doi:10.1002/anie.201307869

18. Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia. Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P. Proc Natl Acad Sci U S A. pubmed:24599591;  doi:10.1073/pnas.1401819111

19. Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib. Wagle N, Grabiner BC, Van Allen EM, Hodis E, Jacobus S, Supko JG, Stewart M, Choueiri TK, Gandhi L, Cleary JM, Elfiky AA, Taplin ME, Stack EC, Signoretti S, Loda M, Shapiro GI, Sabatini D, Lander ES, Gabriel SB, Kantoff PW, Garraway LA, Rosenberg JE. Cancer Discov. pubmed:24625776;  doi:10.1158/2159-8290.CD-13-0353

20. Long noncoding RNAs during normal and malignant hematopoiesis. Alvarez-Dominguez JR, Hu W, Gromatzky AA, Lodish HF. Int J Hematol. pubmed:24609766;  doi:10.1007/s12185-014-1552-8

21. Global analysis of induced transcription factors and cofactors identifies Tfdp2 as an essential coregulator during terminal erythropoiesis. Chen C, Lodish HF. Exp Hematol. pubmed:24607859;  doi:10.1016/j.exphem.2014.03.001

22. Transcriptional divergence and conservation of human and mouse erythropoiesis. Pishesha N, Thiru P, Shi J, Eng JC, Sankaran VG, Lodish HF. Proc Natl Acad Sci U S A. pubmed:24591581;  doi:10.1073/pnas.1401598111

23. Rbfox2 controls autoregulation in RNA-binding protein networks. Jangi M, Boutz PL, Paul P, Sharp PA. Genes Dev. pubmed:24637117;  doi:10.1101/gad.235770.113

24. In vivo delivery of lenti-cre or adeno-cre into mice using intranasal instillation. Gierut JJ, Jacks TE, Haigis KM. Cold Spring Harb Protoc. pubmed:24591689;  doi:10.1101/pdb.prot073445

25. Producing and concentrating lenti-cre for mouse infections. Gierut JJ, Jacks TE, Haigis KM. Cold Spring Harb Protoc. pubmed:24591688;  doi:10.1101/pdb.prot073437

26. Structure-Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response. Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA. J Med Chem. pubmed:24625088;  doi:10.1021/jm401279n

27. A fundamental trade off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. J Biol Chem. pubmed:24634222;  doi:10.1074/jbc.M113.546515

28. SIRT1 and other sirtuins in metabolism. Chang HC, Guarente L. Trends Endocrinol Metab. pubmed:24388149;  doi:10.1016/j.tem.2013.12.001

29. Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. McFadden DG, Papagiannakopoulos T, Taylor-Weiner A, Stewart C, Carter SL, Cibulskis K, Bhutkar A, McKenna A, Dooley A, Vernon A, Sougnez C, Malstrom S, Heimann M, Park J, Chen F, Farago AF, Dayton T, Shefler E, Gabriel S, Getz G, Jacks T. Cell. pubmed:24630729;  doi:10.1016/j.cell.2014.02.031

30. Clioquinol promotes the degradation of metal-dependent amyloid-beta (Abeta) oligomers to restore endocytosis and ameliorate Abeta toxicity. Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S. Proc Natl Acad Sci U S A. pubmed:24591589;  doi:10.1073/pnas.1402228111

31. Regulation of mTORC1 by amino acids. Bar-Peled L, Sabatini DM. Trends Cell Biol. pubmed:24698685;  doi:10.1016/j.tcb.2014.03.003

32. Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer. Mihaylova MM, Sabatini DM, Yilmaz OH. Cell Stem Cell. pubmed:24607404;  doi:10.1016/j.stem.2014.02.008

33. A dual-targeting, p53-independent, apoptosis-inducing platinum(ii) anticancer complex, [Pt(BDI)]Cl. Suntharalingam K, Wilson JJ, Lin W, Lippard SJ. Metallomics. pubmed:24514456;  doi:10.1039/c3mt00364g

34. The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment. Skibinski A, Breindel JL, Prat A, Galvan P, Smith E, Rolfs A, Gupta PB, Labaer J, Kuperwasser C. Cell Rep. pubmed:24613358;  doi:10.1016/j.celrep.2014.02.038

35. SpiroZin1: A Reversible and pH-Insensitive, Reaction-Based, Red-Fluorescent Probe for Imaging Biological Mobile Zinc. Rivera-Fuentes P, Lippard SJ. ChemMedChem. pubmed:24616292;  doi:10.1002/cmdc.201400014

36. Conversion Between Doubly and Triply Carboxylate-Bridged Di(ethylzinc) Complexes and Formation of the (mu-Oxo)tetrazinc Carboxylate [ZnO(ArCO)]. Minier MA, Lippard SJ. Organometallics. pubmed:24761049;  doi:10.1021/om5000503

37. A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl (HNO). Wrobel AT, Johnstone TC, Deliz-Liang A, Lippard SJ, Rivera-Fuentes P. J Am Chem Soc. pubmed:24564324;  doi:10.1021/ja500315x

38. Conjugation of vitamin E analog alpha-TOS to Pt(iv) complexes for dual-targeting anticancer therapy. Suntharalingam K, Song Y, Lippard SJ. Chem Commun (Camb). pubmed:24452361;  doi:10.1039/c3cc48740g

39. Global analysis of cell cycle gene expression of the legume symbiont Sinorhizobium meliloti. De Nisco NJ, Abo RP, Wu CM, Penterman J, Walker GC. Proc Natl Acad Sci U S A. pubmed:24501121;  doi:10.1073/pnas.1400421111

40. Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis. Penterman J, Abo RP, De Nisco NJ, Arnold MF, Longhi R, Zanda M, Walker GC. Proc Natl Acad Sci U S A. pubmed:24501120;  doi:10.1073/pnas.1400450111

41. Coming full circle-from endless complexity to simplicity and back again. Weinberg RA. Cell. pubmed:24679541;  doi:10.1016/j.cell.2014.03.004