The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: February 2014

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Publications Citing Koch Institute Faculty Members

1. Single-cell technologies for monitoring immune systems. Chattopadhyay PK, Gierahn TM, Roederer M, Love JC. Nat Immunol. pubmed:24448570;  doi:10.1038/ni.2796

2. Scalable enhancement of graphene oxide properties by thermally driven phase transformation. Kumar PV, Bardhan NM, Tongay S, Wu J, Belcher AM, Grossman JC. Nat Chem. pubmed:24451592;  doi:10.1038/nchem.1820

3. In vivo discovery of immunotherapy targets in the tumour microenvironment. Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. Nature. pubmed:24476824;  doi:10.1038/nature12988

4. Thermally Switchable Polymers Achieve Controlled Escherichia coli Detachment. Hook AL, Chang CY, Scurr DJ, Langer R, Anderson DG, Williams P, Davies MC, Alexander MR. Adv Healthc Mater. pubmed:24497458;  doi:10.1002/adhm.201300518

5. Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT. Cancer Discov. pubmed:24318931;  doi:10.1158/2159-8290.CD-13-0465

6. Hypoxia promotes liver stage malaria infection in primary human hepatocytes in vitro. Ng S, March S, Galstian A, Hanson K, Carvalho T, Mota MM, Bhatia SN. Dis Model Mech. pubmed:24291761;  doi:10.1242/dmm.013490

7. Transapical mitral implantation of the tiara bioprosthesis: pre-clinical results. Banai S, Verheye S, Cheung A, Schwartz M, Marko A, Lane R, Jolicoeur EM, Garceau P, Biner S, Tanguay JF, Edelman ER, White CJ. JACC Cardiovasc Interv. pubmed:24556094;  doi:10.1016/j.jcin.2013.10.009

8. Molecular Network Analysis of Endometriosis Reveals a Role for c-Jun-Regulated Macrophage Activation. Beste MT, Pfaffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG. Sci Transl Med. pubmed:24500404;  doi:10.1126/scitranslmed.3007988

9. Vapor-Phase Polymerization of Nanofibrillar Poly(3,4-ethylenedioxythiophene) for Supercapacitors. D'Arcy JM, El-Kady MF, Khine PP, Zhang L, Lee SH, Davis NR, Liu DS, Yeung MT, Kim SY, Turner CL, Lech AT, Hammond PT, Kaner RB. ACS Nano. pubmed:24490747;  doi:10.1021/nn405595r

10. The influence of transition metal oxides on the kinetics of LiO oxidation in Li-O batteries: high activity of chromium oxides. Yao KP, Lu YC, Amanchukwu CV, Kwabi DG, Risch M, Zhou J, Grimaud A, Hammond PT, Barde F, Shao-Horn Y. Phys Chem Chem Phys. pubmed:24352578;  doi:10.1039/c3cp53330a

11. Parallel Microfluidic Synthesis of Size-Tunable Polymeric Nanoparticles Using 3D Flow Focusing towards In Vivo Study. Lim JM, Bertrand N, Valencia PM, Rhee M, Langer R, Jon S, Farokhzad OC, Karnik R. Nanomedicine. pubmed:23969105;  doi:10.1016/j.nano.2013.08.003

12. Crossword: A Fully Automated Algorithm for the Segmentation and Quality Control of Protein Microarray Images. Gierahn TM, Loginov D, Love JC. J Proteome Res. pubmed:24417579;  doi:10.1021/pr401167h

13. Measuring single cell mass, volume, and density with dual suspended microchannel resonators. Bryan AK, Hecht VC, Shen W, Payer K, Grover WH, Manalis SR. Lab Chip. pubmed:24296901;  doi:10.1039/c3lc51022k

14. A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal short-term synaptic plasticity and vesicle number. Walters BJ, Hallengren JJ, Theile CS, Ploegh HL, Wilson SM, Dobrunz LE. J Physiol. pubmed:24218545;  doi:10.1113/jphysiol.2013.266015

15. A polygenic burden of rare disruptive mutations in schizophrenia. Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kahler A, Duncan L, Stahl E, Genovese G, Fernandez E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, Depristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P. Nature. pubmed:24463508;  doi:10.1038/nature12975

16. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Nat Struct Mol Biol. pubmed:24463464;  doi:10.1038/nsmb.2764

17. Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL. J Exp Med. pubmed:24493799;  doi:10.1084/jem.20131603

18. Meeting global challenges. Sharp PA, Leshner AI. Science. pubmed:24503818;  doi:10.1126/science.1250725

19. Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II. Zamudio JR, Kelly TJ, Sharp PA. Cell. pubmed:24581493;  doi:10.1016/j.cell.2014.01.041

20. Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself. Weight AK, Belser JA, Tumpey TM, Chen J, Klibanov AM. Pharm Res. pubmed:24065587;  doi:10.1007/s11095-013-1175-4

21. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21. Li Y, Wong K, Giles A, Jiang J, Lee JW, Adams AC, Kharitonenkov A, Yang Q, Gao B, Guarente L, Zang M. Gastroenterology. pubmed:24184811;  doi:10.1053/j.gastro.2013.10.059

22. SIRT1 in Neurodevelopment and Brain Senescence. Herskovits AZ, Guarente L. Neuron. pubmed:24507186;  doi:10.1016/j.neuron.2014.01.028

23. Splice isoform and pharmacological studies reveal that sterol depletion relocalizes alpha-synuclein and enhances its toxicity. Valastyan JS, Termine DJ, Lindquist S. Proc Natl Acad Sci U S A. pubmed:24516169;  doi:10.1073/pnas.1324209111

24. Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics. Frederick KK, Debelouchina GT, Kayatekin C, Dorminy T, Jacavone AC, Griffin RG, Lindquist S. Chem Biol. pubmed:24485763;  doi:10.1016/j.chembiol.2013.12.013

25. The Caenorhabditis elegans Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9. de la Cruz IP, Ma L, Horvitz HR. PLoS Genet. pubmed:24586202;  doi:10.1371/journal.pgen.1004175

26. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation. Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH. Cell Death Differ. pubmed:24510127;  doi:10.1038/cdd.2014.8

27. SYK Is a Critical Regulator of FLT3 in Acute Myeloid Leukemia. Puissant A, Fenouille N, Alexe G, Pikman Y, Bassil CF, Mehta S, Du J, Kazi JU, Luciano F, Ronnstrand L, Kung AL, Aster JC, Galinsky I, Stone RM, Deangelo DJ, Hemann MT, Stegmaier K. Cancer Cell. pubmed:24525236;  doi:10.1016/j.ccr.2014.01.022

28. Central role for RNase YbeY in Hfq-dependent and Hfq-independent small-RNA regulation in bacteria. Pandey SP, Winkler JA, Li H, Camacho DM, Collins JJ, Walker GC. BMC Genomics. pubmed:24511998;  doi:10.1186/1471-2164-15-121

29. Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH) Cl (OH) ]. Johnstone TC, Lippard SJ. J Biol Inorg Chem. pubmed:24515615;  doi:10.1007/s00775-014-1109-6

30. Diiron Oxidation State Control of Substrate Access to the Active Site of Soluble Methane Monooxygenase Mediated by the Regulatory Component. Wang W, Lippard SJ. J Am Chem Soc. pubmed:24476336;  doi:10.1021/ja412351b

31. The Chiral Potential of Phenanthriplatin and Its Influence on Guanine Binding. Johnstone TC, Lippard SJ. J Am Chem Soc. pubmed:24417436;  doi:10.1021/ja4125115