The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: June 2012

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

1.  The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation
Jun HJ, Johnson H, Bronson RT, de Feraudy S, White F, Charest A
Publication: Cancer Research
DOI: 10.1158/0008-5472.CAN-11-3990
E-Publication Date: June 1, 2012 

*2.  Toward quantitative phosphotyrosine profiling in vivo
Johnson H, White FM
Publication: Seminars in Cell & Developmental Biology
DOI: 10.1016/j.semcdb.2012.05.008
E-Publication Date: June 4, 2012 

*3.  Labeling and identification of direct kinase substrates
Carlson SM, White FM
Publication: Science Signaling
DOI: 10.1126/scisignal.2002568
E-Publication Date: June 5, 2012

*4.  Tuning Smart Microgel Swelling and Responsive Behavior through Strong and Weak Polyelectrolyte Pair Assembly
Costa E, Lloyd MM, Chopko C, Aguiar-Ricardo A, Hammond PT
Publication: Langmuir
DOI: 10.1021/la301586t
E-Publication Date: June 7, 2012

*5.  Systematic Single-Cell Analysis of Pichia pastoris Reveals Secretory Capacity Limits Productivity
Love KR, Politano TJ, Panagiotou V, Jiang B, Stadheim TA, Love JC
Publication: PLoS One
DOI: 10.1371/journal.pone.0037915
E-Publication Date: June 7, 2012

6.  Stimulation of MC38 tumor growth by insulin analog X10 involves the serine synthesis pathway
Hvid H, Fendt SM, Blouin MJ, Birman E, Voisin G, Svendsen AM, Frank R, Vander Heiden MG, Stephanopoulos G, Hansen BF, Pollak M
Publication: RNA Biology
DOI: 10.1530/ERC-12-0125
E-Publication Date: June 8, 2012

*7.  Proliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of DICER1
Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA
Publication: Cancer Cell
DOI: 10.1016/j.ccr.2012.04.037
E-Publication Date: June 11, 2012

*8.  FRET-Labeled siRNA Probes for Tracking Assembly and Disassembly of siRNA Nanocomplexes
Alabi CA, Love KT, Sahay G, Stutzman T, Young WT, Langer R, Anderson DG
Publication: ACS Nano
DOI: 10.1021/nn3013838
E-Publication Date: June 13, 2012

*9.  Triepitopic Antibody Fusions Inhibit Cetuximab-Resistant BRAF and KRAS Mutant Tumors via EGFR Signal Repression
Spangler JB, Manzari MT, Rosalia EK, Chen TF, Wittrup KD
Publication: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2012.06.014
E-Publication Date: June 14, 2012

10.  An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia
Li L, Welser-Alves J, van der Flier A, Boroujerdi A, Hynes RO, Milner R
Publication: Experimental Neurology
DOI: 10.1016/j.expneurol.2012.06.005
E-Publication Date: June 18, 2012

*11.  Control of the Mitotic Exit Network during meiosis
Attner MA, Amon A
Publication: Molecular Biology of the Cell
DOI: 10.1091/mbc.E12-03-0235
E-Publication Date: June 20, 2012

*12.  Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices
Kim Y, Lee Chung B, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R
Publication: Nano Letters
DOI: 10.1021/nl301253v
E-Publication Date: June 20, 2012

*13.  Attacking the genome: emerging siRNA nanocarriers from concept to clinic
Alabi C, Vegas A, Anderson D
Publication: Current Opinion in Pharmacology
DOI: 10.1016/j.coph.2012.05.004
E-Publication Date: June 21, 2012

*14.  Signaling for death: tyrosine phosphorylation in the response to glucose deprivation
Bryson BD, White FM
Publication: Molecular Systems Biology
DOI: 10.1038/msb.2012.27
E-Publication Date: June 26, 2012

*15.  Exploiting Synthetic Lethal Interactions Between DNA Damage Signaling, Checkpoint Control, and p53 for Targeted Cancer Therapy
Morandell S, Yaffe MB
Publication: Progress in Molecular Biology and Translational Science
DOI: 10.1016/B978-0-12-387665-2.00011-0
E-Publication Date: June 27, 2012 

16.  The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response
Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP
Publication: PLoS Pathogens
DOI: 10.1371/journal.ppat.1002784
E-Publication Date: June 28, 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

*17.  2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen
Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA
Publication: Journal of Cell Biology
DOI: 10.1083/jcb.201201003
E-Publication Date: June 4, 2012

*18.  Attachment of Chlamydia trachomatis L2 to host cells requires sulfation
Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1120244109
E-Publication Date: June 6, 2012

*19.  How to regulate a gene: to repress or to activate?
Slavov N, van Oudenaarden A
Publication: Molecular Cell
DOI: 10.1016/j.molcel.2012.05.035
E-Publication Date: June 7, 2012

*20.  DNA repair is indispensable for survival after acute inflammation
Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI63338
E-Publication Date: June 11, 2012

*21.  miR-125b transforms myeloid cell lines by repressing multiple mRNA targets
Bousquet M, Nguyen D, Chen C, Schields L, Lodish H
Publication: Haematologica
DOI: 10.3324/haematol.2011.061515
E-Publication Date: June 11, 2012

22.  The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H
Publication: The EMBO Journal
DOI: 10.1038/emboj.2012.166
E-Publication Date: June 12, 2012

23.  NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase η
Pozhidaeva A, Pustovalova Y, D'Souza S, Bezsonova I, Walker GC, Korzhnev DM
Publication: Biochemistry
DOI: 10.1021/bi300566z
E-Publication Date: June 13, 2012

*24.  Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans
Omura DT, Clark DA, Samuel AD, Horvitz HR
Publication: PloS One
DOI: 10.1371/journal.pone.0038649
E-Publication Date: June 13, 2012

25.  Multifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κ
Wojtaszek J, Liu J, D'Souza S, Wang S, Xue Y, Walker GC, Zhou P
Publication: Journal of Biological Chemistry
DOI: 10.1074/jbc.M112.380998
E-Publication Date: June 14, 2012

26.  UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit
Schneider J, Skelton RL, Von Stetina SE, Middelkoop TC, van Oudenaarden A, Korswagen HC, Miller DM 3rd
Publication: Development
DOI: 10.1242/dev.075184
E-Publication Date: June 15, 2012

*27.  Zinc Thiolate Reactivity toward Nitrogen Oxides: Insights into the Interaction of Zn(2+) with S-Nitrosothiols and Implications for Nitric Oxide Synthase
Kozhukh J, Lippard SJ
Publication: Inorganic Chemistry
DOI: 10.1021/ic3007684
E-Publication Date: June 15, 2012

*28.  Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia
Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI63597
E-Publication Date: June 18, 2012 

29.  Sequence analysis of mutations and translocations across breast cancer subtypes
Banerji S, Cibulskis K, Rangel-Escareno C, Brown KK, Carter SL, Frederick AM, Lawrence MS, Sivachenko AY, Sougnez C, Zou L, Cortes ML, Fernandez-Lopez JC, Peng S, Ardlie KG, Auclair D, Bautista-Piña V, Duke F, Francis J, Jung J, Maffuz-Aziz A, Onofrio RC, Parkin M, Pho NH, Quintanar-Jurado V, Ramos AH, Rebollar-Vega R, Rodriguez-Cuevas S, Romero-Cordoba SL, Schumacher SE, Stransky N, Thompson KM, Uribe-Figueroa L, Baselga J, Beroukhim R, Polyak K, Sgroi DC, Richardson AL, Jimenez-Sanchez G, Lander ES, Gabriel SB, Garraway LA, Golub TR, Melendez-Zajgla J, Toker A, Getz G, Hidalgo-Miranda A, Meyerson M
Publication: Nature
DOI: 10.1038/nature11154
E-Publication Date: June 20, 2012

*30.  Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity
McLellan CA, Whitesell L, King OD, Lancaster AK, Mazitschek R, Lindquist S
Publication: ACS Chemical Biology
DOI: 10.1021/cb300235m
E-Publication Date: June 22, 2012

*31.  Conserved features of intermediates in amyloid assembly determine their benign or toxic states
Krishnan R, Goodman JL, Mukhopadhyay S, Pacheco CD, Lemke EA, Deniz AA, Lindquist S
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1209527109
E-Publication Date: June 27, 2012

32.  Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H(2)S and S-Nitrosothiols
Filipovic MR, Miljkovic JLj, Nauser T, Royzen M, Klos K, Shubina T, Koppenol WH, Lippard SJ, Ivanović-Burmazović I
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja3009693
E-Publication Date: June 28, 2012

*33.  Influence of Tetraazamacrocyclic Ligands on the Nitric Oxide Reactivity of their Cobalt(II) Complexes
Kozhukh J, Lippard SJ
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja305011g
E-Publication Date: June 28, 2012

*34.  Amino acids and mTORC1: from lysosomes to disease
Efeyan A, Zoncu R, Sabatini DM
Publication: Trends in Molecular Medicine
DOI: 10.1016/j.molmed.2012.05.007
E-Publication Date: June 28, 2012

*35.  A C(2)-symmetric, basic Fe(iii) carboxylate complex derived from a novel triptycene-based chelating carboxylate ligand
Li Y, Wilson JJ, Do LH, Apfel UP, Lippard SJ
Publication: Dalton Transactions
DOI: 10.1039/C2DT31260C
E-Publication Date: June 29, 2012