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The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: May 2012

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

*1.  Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm
Leung A, Todorova T, Ando Y, Chang P
Publication: RNA Biology
DOI: 10.4161/rna.19899
E-Publication Date: May 1, 2012

2.  YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
Li J, Song JS, Bell RJ, Tran TN, Haq R, Liu H, Love KT, Langer R, Anderson DG, Larue L, Fisher DE
Publication: PLoS Genetics
DOI: 10.1371/journal.pgen.1002688
E-Publication Date: May 3, 2012

3.  Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging
Mieszawska AJ, Gianella A, Cormode DP, Zhao Y, Meijerink A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ
Publication: Chemical Communications
DOI: 10.1039/C2CC32149A
E-Publication Date: May 3, 2012

*4.  Melanin-like Hydrogels Derived from Gallic Macromers
Fisher OZ, Larson BL, Hill PS, Graupner D, Nguyen-Kim MT, Kehr NS, De Cola L, Langer R, Anderson DG
Publication: Advanced Materials
DOI: 10.1002/adma.201104437
E-Publication Date: May 7, 2012

5.  Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1
Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR Jr
Publication: ChemBioChem
DOI: 10.1002/cbic.201200206
E-Publication Date: May 8, 2012

*6.  Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, Macbeath G, Yaffe MB
Publication: Cell
DOI: 10.1016/j.cell.2012.03.031
E-Publication Date: May 10, 2012 

*7.  Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model
Masi BC, Tyler BM, Bow H, Wicks RT, Xue Y, Brem H, Langer R, Cima MJ
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.04.048
E-Publication Date: May 14, 2012

8.  Peptide Array X-Linking (PAX): A New Peptide-Protein Identification Approach
Okada H, Uezu A, Soderblom EJ, Moseley MA 3rd, Gertler FB, Soderling SH
Publication: PLoS One
DOI: 10.1371/journal.pone.0037035
E-Publication Date: May 14, 2012

*9.  Expanding applications of chemical genetics in signal transduction
Carlson SM, White FM
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.03.023
E-Publication Date: May 15, 2012

*10.  Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles
Stephan MT, Stephan SB, Bak P, Chen J, Irvine DJ
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.04.029
E-Publication Date: May 15, 2012

11.  Electrospun drug-eluting sutures for local anesthesia
Weldon CB, Tsui JH, Shankarappa SA, Nguyen VT, Ma M, Anderson DG, Kohane DS
Publication: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2012.05.021
E-Publication Date: May 17, 2012

*12.  Chromosomal instability and aneuploidy in cancer: from yeast to man
Pfau SJ, Amon A
Publication: EMBO Reports
DOI: 10.1038/embor.2012.65
E-Publication Date: May 22, 2012

13.  Strategies for MCR image analysis of large hyperspectral data-sets
Scurr DJ, Hook AL, Burley J, Williams PM, Anderson DG, Langer R, Davies MC, Alexander MR
Publication: Surface and Interface Analysis
DOI: 10.1002/sia.5040
E-Publication Date: May 22, 2012

*14.  Virus-templated iridium oxide-gold hybrid nanowires for electrochromic application
Nam YS, Park H, Magyar AP, Yun DS, Pollom TS, Belcher AM
Publication: Nanoscale
DOI: 10.1039/C2NR30115F
E-Publication Date: May 23, 2012

15.  GAS41 amplification results in overexpression of a new spindle pole protein
Schmitt J, Fischer U, Heisel S, Strickfaden H, Backes C, Ruggieri A, Keller A, Chang P, Meese E
Publication: Genes, Chromosomes and Cancer
DOI: 10.1002/gcc.21971
E-Publication Date: May 23, 2012

*16.  Engineering Nano- and Microparticles to Tune Immunity
Moon JJ, Huang B, Irvine DJ
Publication: Advanced Materials
DOI: 10.1002/adma.201200446
E-Publication Date: May 29, 2012

*17.  Glycosylation at Asn91 of H1N1 haemagglutinin affects binding to glycan receptors
Jayaraman A, Koh X, Li J, Raman R, Viswanathan K, Shriver Z, Sasisekharan R
Publication: Biochemical Journal
DOI: 10.1042/BJ20112101
E-Publication Date: May 29, 2012

*18.  Building biomedical materials layer-by-layer
Hammond PT
Publication: Materials Today
DOI: 10.1016/S1369-7021(12)70090-1
E-Publication Date: May 29, 2012

*19.  Polyelectrolyte multilayered nanoparticles: using nanolayers for controlled and targeted systemic release
Hammond PT
Publication: Nanomedicine (London)
DOI: DOI 10.2217/nnm.12.47
E-Publication Date: May 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

20.  SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI60132
E-Publication Date: May 1, 2012 

21.  Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks
Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK
Publication: BMC Systems Biology
DOI: 10.1186/1752-0509-6-29
E-Publication Date: May 1, 2012 

22.  TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK
Publication: Cell Metabolism
DOI: 10.1016/j.cmet.2012.04.007
E-Publication Date: May 1, 2012 

*23.  A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM
Publication: Nature
DOI: 10.1038/nature11083
E-Publication Date: May 2, 2012

*24.  Fast, cell-compatible click chemistry with copper-chelating azides for biomolecular labeling
Uttamapinant C, Tangpeerachaikul A, Grecian S, Clarke S, Singh U, Slade P, Gee KR, Ting AY
Publication: Angewandte Chemie International Edition
DOI: 10.1002/anie.201108181
E-Publication Date: May 3, 2012

*25.  Grounded: Transcriptional Pausing in Naive mESCs
Guenther MG, Young RA
Publication: Cell Stem Cell
DOI: 10.1016/j.stem.2012.04.016
E-Publication Date: May 4, 2012

26.  The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C
Publication: Bioorganic & Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2012.04.124
E-Publication Date: May 4, 2012 

27.  Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome
Galili N, Tamayo P, Botvinnik OB, Mesirov JP, Brooks MR, Brown G, Raza A
Publication: Journal of Hematology and Oncology
DOI: 10.1186/1756-8722-5-20
E-Publication Date: May 6, 2012

28.  Prion formation by a yeast GLFG nucleoporin
Halfmann R, Wright J, Alberti S, Lindquist S, Rexach M
Publication: Prion
DOI: 10.4161/pri.20199
E-Publication Date: May 7, 2012

29.  Melanoma genome sequencing reveals frequent PREX2 mutations
Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA
Publication: Nature
DOI: 10.1038/nature11071
E-Publication Date: May 9, 2012

*30.  α(V)β(3) Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug
Graf N, Bielenberg DR, Kolishetti N, Muus C, Banyard J, Farokhzad OC, Lippard SJ
Publication: ACS Nano
DOI: 10.1021/nn301148e
E-Publication Date: May 14, 2012 

*31.  MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma
Wood KC, Konieczkowski DJ, Johannessen CM, Boehm JS, Tamayo P, Botvinnik OB, Mesirov JP, Hahn WC, Root DE, Garraway LA, Sabatini DM
Publication: Science Signaling
DOI: 10.1126/scisignal.2002612
E-Publication Date: May 15, 2012

*32.  Identification of Novel Human Damage Response Proteins Targeted through Yeast Orthology
Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD
Publication: PLoS One
DOI: 10.1371/journal.pone.0037368
E-Publication Date: May 15, 2012 

33.  Identification of molecular compartments and genetic circuitry in the developing mammalian kidney
Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP
Publication: Development
DOI: 10.1242/dev.074005
E-Publication Date: May 16, 2012 

34.  Development of an Influenza virus Protein Array Using Sortagging Technology
Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L
Publication: Bioconjugate Chemistry
DOI: 10.1021/bc200577u
E-Publication Date: May 17, 2012

*35.  Separation of DNA replication from the assembly of break-competent meiotic chromosomes
Blitzblau HG, Chan CS, Hochwagen A, Bell SP
Publication: PLoS Genetics
DOI: 10.1371/journal.pgen.1002643
E-Publication Date: May 17, 2012 

*36.  In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands
Wilson JJ, Lippard SJ
Publication: Journal of Medicinal Chemistry
DOI: 10.1021/jm3002857
E-Publication Date: May 18, 2012 

*37.  The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions
Shibue T, Brooks MW, Inan MF, Reinhardt F, Weinberg RA
Publication: Cancer Discovery
DOI: 10.1158/2159-8290.CD-11-0239
E-Publication Date: May 18, 2012 

38.  An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, Veh R, Ninnemann O, Peters O, Nitsch R, Heppner FL, Golenbock D, Schott E, Ploegh HL, Wulczyn FG, Lehnardt S
Publication: Nature Neuroscience
DOI: 10.1038/nn.3113
E-Publication Date: May 20, 2012 

39.  Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, Macdonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA
Publication: Nature Genetics
DOI: 10.1038/ng.2279
E-Publication Date: May 20, 2012 

*40.  mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM
Publication: Nature
DOI: 10.1038/nature11163
E-Publication Date: May 20, 2012

*41.  A viral deubiquitylating enzyme restores dislocation of substrates from the ER in semi-intact cells
Sanyal S, Claessen JH, Ploegh HL
Publication: Journal of Biological Chemistry
DOI: 10.1074/jbc.M112.365312
E-Publication Date: May 22, 2012