The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: April 2012

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

*1.  Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer
Urbanska AM, Karagiannis ED, Guajardo G, Langer RS, Anderson DG
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.03.023
E-Publication Date: April 1, 2012

*2.  Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics
Radovic-Moreno AF, Lu TK, Puscasu VA, Yoon CJ, Langer R, Farokhzad OC
Publication: ACS Nano
DOI: 10.1021/nn3008383
E-Publication Date: April 3, 2012

*3.  Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile
Hrkach J, Von Hoff D, Mukkaram Ali M, Andrianova E, Auer J, Campbell T, De Witt D, Figa M, Figueiredo M, Horhota A, Low S, McDonnell K, Peeke E, Retnarajan B, Sabnis A, Schnipper E, Song JJ, Song YH, Summa J, Tompsett D, Troiano G, Van Geen Hoven T, Wright J, LoRusso P, Kantoff PW, Bander NH, Sweeney C, Farokhzad OC, Langer R, Zale S
Publication: Science Translational Medicine
DOI: 10.1126/scitranslmed.3003651
E-Publication Date: April 4, 2012

*4.  Effect of Small-Molecule-Binding Affinity on Tumor Uptake In Vivo: A Systematic Study Using a Pretargeted Bispecific Antibody
Orcutt KD, Rhoden JJ, Ruiz-Yi B, Frangioni JV, Wittrup KD
Publication: Molecular Cancer Therapeutics
DOI: 10.1158/1535-7163.MCT-11-0764
E-Publication Date: April 5, 2012

*5.  Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies
Leskov I, Pallasch CP, Drake A, Iliopoulou BP, Souza A, Shen CH, Schweighofer CD, Abruzzo L, Frenzel LP, Wendtner CM, Hemann MT, Chen J
Publication: Oncogene
DOI: 10.1038/onc.2012.117
E-Publication Date: April 9, 2012

*6.  Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation
Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja301621z
E-Publication Date: April 10, 2012

*7.  Stem cell membrane engineering for cell rolling using peptide conjugation and tuning of cell-selectin interaction kinetics
Cheng H, Byrska-Bishop M, Zhang CT, Kastrup CJ, Hwang NS, Tai AK, Lee WW, Xu X, Nahrendorf M, Langer R, Anderson DG
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.03.065
E-Publication Date: April 10, 2012

8.  Computational approaches for analyzing information flow in biological networks
Kholodenko B, Yaffe MB, Kolch W
Publication: Science Signaling
DOI: DOI: 10.1126/scisignal.2002961
E-Publication Date: April 17, 2012

9.  Biotemplated synthesis of perovskite nanomaterials for solar energy conversion
Nuraje N, Dang X, Qi J, Allen MA, Lei Y, Belcher AM
Publication: Advanced Materials
DOI: DOI: 10.1002/adma.201200114
E-Publication Date: April 20, 2012

*10.  Harnessing glycomics technologies: Integrating structure with function for glycan characterization
Robinson LN, Artpradit C, Raman R, Shriver ZH, Ruchirawat M, Sasisekharan R
Publication: Electrophoresis
DOI: 10.1002/elps.201100231
E-Publication Date: April 23, 2012

*11.  Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice
Crook ZR, Housman DE
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1204542109
E-Publication Date: April 23, 2012

*12.  A microfluidic "baby machine" for cell synchronization
Shaw J, Payer K, Son S, Grover WH, Manalis SR
Publication: Lab on a Chip
DOI: 10.1039/C2LC40277G
E-Publication Date: April 24, 2012

*13.  Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm
Leung A, Todorova T, Ando Y, Chang P
Publication: RNA Biology
DOI: 10.4161/rna.19899
E-Publication Date: April 26, 2012

*14.  Roles for MicroRNAs in Conferring Robustness to Biological Processes
Ebert MS, Sharp PA
Publication: Cell
DOI: 10.1016/j.cell.2012.04.005
E-Publication Date: April 26, 2012

15.  Reduced Expression of Ribosomal Proteins Relieves MicroRNA-Mediated Repression
Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD
Publication: Molecular Cell
DOI: 10.1016/j.molcel.2012.04.008
E-Publication Date: April 27, 2012

*16.  In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs
Gurtan AM, Lu V, Bhutkar A, Sharp PA
Publication: RNA
DOI: 10.1261/rna.032680.112
E-Publication Date: April 30, 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

*17.  The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO
Boulias K, Horvitz HR
Publication: Cell Metabolism
DOI: 10.1016/j.cmet.2012.02.014
E-Publication Date: April 3, 2012

18.  The genomic basis of adaptive evolution in threespine sticklebacks
Jones FC, Grabherr MG, Chan YF, Russell P, Mauceli E, Johnson J, Swofford R, Pirun M, Zody MC, White S, Birney E, Searle S, Schmutz J, Grimwood J, Dickson MC, Myers RM, Miller CT, Summers BR, Knecht AK, Brady SD, Zhang H, Pollen AA, Howes T, Amemiya C; Broad Institute Genome Sequencing Platform & Whole Genome Assembly Team, Baldwin J, Bloom T, Jaffe DB, Nicol R, Wilkinson J, Lander ES, Di Palma F, Lindblad-Toh K, Kingsley DM
Publication: Nature
DOI: 10.1038/nature10944
E-Publication Date: April 4, 2012

*19.  Site-specific protein modification using lipoic Acid ligase and bis-aryl hydrazone formation
Cohen JD, Zou P, Ting AY
Publication: Chembiochem
DOI: 10.1002/cbic.201100764
E-Publication Date: April 11, 2012

20.  Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae
Liu Q, Ren T, Fresques T, Oppliger W, Niles BJ, Hur W, Sabatini DM, Hall MN, Powers T, Gray NS
Publication: ACS Chemical Biology
DOI: 10.1021/cb300058v
E-Publication Date: April 11, 2012

*21.  mTOR Signaling in Growth Control and Disease
Laplante M, Sabatini DM
Publication: Cell
DOI: 10.1016/j.cell.2012.03.017
E-Publication Date: April 12, 2012

22.  SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo
Bobrowska A, Donmez G, Weiss A, Guarente L, Bates G
Publication: PLoS One
DOI: 10.1371/journal.pone.0034805
E-Publication Date: April 12, 2012

*23.  Using gene expression noise to understand gene regulation
Munsky B, Neuert G, van Oudenaarden A
Publication: Science
DOI: 10.1126/science.1216379
E-Publication Date: April 13, 2012

24.  Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to Fas Ligand
Rodrigues M, Turner O, Stolz D, Griffith LG, Wells A
Publication: Cell Transplantation
DOI: 10.3727/096368912X639035
E-Publication Date: April 17, 2012

*25.  Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
Thorvaldsdóttir H, Robinson JT, Mesirov JP
Publication: Briefings in Bioinformatics
DOI: 10.1093/bib/bbs017
E-Publication Date: April 19, 2012

*26.  Oxidation of the guanine nucleotide pool underlies cell death by bactericidal antibiotics
Foti JJ, Devadoss B, Winkler JA, Collins JJ, Walker GC
Publication: Science
DOI: 10.1126/science.1219192
E-Publication Date: April 20, 2012

27.  Active site residues critical for flavin binding and 5,6-dimethylbenzimidazole biosynthesis in the flavin destructase enzyme BluB
Yu TY, Mok KC, Kennedy KJ, Valton J, Anderson KS, Walker GC, Taga ME
Publication: Protein Science
DOI: 10.1002/pro.2068
E-Publication Date: April 23, 2012

*28.  An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component
Treusch S, Lindquist S
Publication: Journal of Cell Biology
DOI: 10.1083/jcb.201108146
E-Publication Date: April 23, 2012

*29.  Cancer stem cells and epithelial-mesenchymal transition: Concepts and molecular links
Scheel C, Weinberg RA
Publication: Seminars in Cancer Biology
DOI: 10.1016/j.semcancer.2012.04.001
E-Publication Date: April 23, 2012

30.  Integrated Molecular Analysis Indicates Undetectable DNA Damage in Mice after Continuous Irradiation at ~400-fold Natural Background Radiation
Olipitz W, Wiktor-Brown D, Shuga J, Pang B, McFaline J, Lonkar P, Thomas A, Mutamba JT, Greenberger JS, Samson LD, Dedon PC, Yanch JC, Engelward BP
Publication: Environmental Health Perspectives
DOI: 10.1289/ehp.1104294
E-Publication Date: April 26, 2012

*31.  CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection
Sehrawat S, Kirak O, Koenig P, Isaacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R, Ploegh HL
Publication: Cell Reports
DOI: 10.1016/j.celrep.2012.03.009
E-Publication Date: April 26, 2012

32.  Absolute quantification of somatic DNA alterations in human cancer
Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G
Publication: Nature Biotechnology
DOI: 10.1038/nbt.2203
E-Publication Date: April 29, 2012