The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Progress: November 2012

Return to Progress index

Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

1.  Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility
Hashimoto M, Langer R, Kohane DS
Publication: Lab on a Chip
DOI: 10.1039/C2LC40888K
E-Publication Date: November 7, 2012

2.  Formulations for trans-tympanic antibiotic delivery
Khoo X, Simons EJ, Chiang HH, Hickey JM, Sabharwal V, Pelton SI, Rosowski JJ, Langer R, Kohane DS
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2012.10.025
E-Publication Date: November 9, 2012 

3.  Nonendocytic Delivery of Functional Engineered Nanoparticles into the Cytoplasm of Live Cells Using a Novel, High-Throughput Microfluidic Device
Lee J, Sharei A, Sim WY, Adamo A, Langer R, Jensen KF, Bawendi MG
Publication: Nano Letters
DOI: 10.1021/nl303421h
E-Publication Date: November 12, 2012

*4.  Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation
Landman AS, Danielian PS, Lees JA
Publication: Oncogene
DOI: 10.1038/onc.2012.496
E-Publication Date: November 12, 2012

5.  Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion
Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS
Publication: Cancer Cell
DOI: 10.1016/j.ccr.2012.09.027
E-Publication Date: November 12, 2012

6.  What is the greatest regulatory challenge in the translation of biomaterials to the clinic?
Prestwich GD, Bhatia S, Breuer CK, Dahl SL, Mason C, McFarland R, McQuillan DJ, Sackner-Bernstein J, Schox J, Tente WE, Trounson A
Publication: Science Translational Medicine
DOI: 10.1126/scitranslmed.3004915
E-Publication Date: November 14, 2012

*7.  Rapid Conformational Epitope Mapping of Anti-gp120 Antibodies with a Designed Mutant Panel Displayed on Yeast
Mata-Fink J, Kriegsman B, Yu HX, Zhu H, Hanson MC, Irvine DJ, Wittrup KD
Publication: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2012.11.010
E-Publication Date: November 15, 2012

*8.  Understanding resistance to combination chemotherapy
Pritchard JR, Lauffenburger DA, Hemann MT
Publication: Drug Resistance Updates
DOI: 10.1016/j.drup.2012.10.003
E-Publication Date: November 16, 2012

*9.  The Initial Hours of Metastasis: The Importance of Cooperative Host-Tumor Cell Interactions during Hematogenous Dissemination
Labelle M, Hynes RO
Publication: Cancer Discovery
DOI: 10.1158/2159-8290.CD-12-0329
E-Publication Date: November 19, 2012

10.  A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance
Yazaki PJ, Lee B, Channappa D, Cheung CW, Crow D, Chea J, Poku E, Li L, Andersen JT, Sandlie I, Orcutt KD, Wittrup KD, Shively JE, Raubitschek A, Colcher D
Publication: Protein Engineering, Design and Selection
DOI: 10.1093/protein/gzs096
E-Publication Date: November 21, 2012

11.  T-cell death following immune activation is mediated by mitochondria-localized SARM
Panneerselvam P, Singh LP, Selvarajan V, Chng WJ, Ng SB, Tan NS, Ho B, Chen J, Ding JL
Publication: Cell Death and Differentiation
DOI: 10.1038/cdd.2012.144
E-Publication Date: November 23, 2012

*12.  Polymer-attached zanamivir inhibits synergistically both early and late stages of influenza virus infection
Lee CM, Weight AK, Haldar J, Wang L, Klibanov AM, Chen J
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1219155109
E-Publication Date: November 26, 2012

13.  Three-Dimensional Elastomeric Scaffolds Designed with Cardiac-Mimetic Structural and Mechanical Features
Neal RA, Jean A, Park H, Wu PB, Hsiao J, Engelmayr GC Jr, Langer R, Freed LE
Publication: Tissue Engineering Part A
DOI: 10.1089/ten.tea.2012.0330
E-Publication Date: November 28, 2012

*14.  The dynamic lives of T cells: new approaches and themes
Yamanaka YJ, Gierahn TM, Love JC
Publication: Trends in Immunology
DOI: 10.1016/j.celrep.2012.10.021
E-Publication Date: November 28, 2012

15.  FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression
Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M
Publication: Cell Reports
DOI: 10.1016/
E-Publication Date: November 29, 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

16.  Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability
Drier Y, Lawrence MS, Carter SL, Stewart C, Gabriel SB, Lander ES, Meyerson M, Beroukhim R, Getz G
Publication: Genome Research
DOI: 10.1101/gr.141382.112
E-Publication Date: November 2, 2012

*17.  Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand
Hope JM, Wilson JJ, Lippard SJ
Publication: Dalton Transactions
DOI: 10.1039/C2DT32462H
E-Publication Date: November 6, 2012

18. Emerging disease or diagnosis?
Gire SK, Stremlau M, Andersen KG, Schaffner SF, Bjornson Z, Rubins K, Hensley L, McCormick JB, Lander ES, Garry RF, Happi C, Sabeti PC
Publication: Science
DOI: 10.1126/science.1225893
E-Publication Date: November 9, 2012

19.  IRK-1 Potassium Channels Mediate Peptidergic Inhibition of Caenorhabditis elegans Serotonin Neurons via a Go Signaling Pathway
Emtage L, Aziz-Zaman S, Padovan-Merhar O, Horvitz HR, Fang-Yen C, Ringstad N
Publication: The Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.2667-12.2012
E-Publication Date: November 14, 2012

20.  Directional cell migration in an extracellular pH gradient: A model study with an engineered cell line and primary microvascular endothelial cells
Paradise RK, Whitfield MJ, Lauffenburger DA, Van Vliet KJ
Publication: Experimental Cell Research
DOI: 10.1016/j.yexcr.2012.11.006
E-Publication Date: November 12, 2012

21.  Multiplexed Protease Activity Assay for Low-Volume Clinical Samples Using Droplet-Based Microfluidics and Its Application to Endometriosis
Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja307866z
E-Publication Date: November 18, 2012

*22.  Transdifferentiation by defined factors as a powerful research tool to address basic biological questions
Buganim Y, Jaenisch R
Publication: Cell Cycle
DOI: 10.4161/cc.22665
E-Publication Date: November 19, 2012

23.  Anti-Atherosclerotic Therapy Based on Botanicals
Orekhov AN, Sobenin IA, Korneev NV, Kirichenko TV, Myasoedova VA, Melnichenko AA, Balcells M, Edelman ER, Bobryshev YV
Publication: Recent Patents on Cardiovascular Drug discovery
E-Publication Date: November 22, 2012

*24.  Quantum Dot Targeting with Lipoic Acid Ligase and HaloTag for Single-Molecule Imaging on Living Cells
Liu DS, Phipps WS, Loh KH, Howarth M, Ting AY
Publication: ACS Nano
DOI: 10.1021/nn304793z
E-Publication Date: November 26, 2012 

*25.  Cell-cycle-dependent transcriptional and translational DNA-damage response of ribonucleotide reductase genes in S. cerevisiae
Mazumder A, Tummler K, Bathe M, Samson LD
Publication: Molecular and Cellular Biology
DOI: 10.1128/MCB.01020-12
E-Publication Date: November 26, 2012

*26.  iPSC Disease Modeling
Soldner F, Jaenisch R
Publication: Science
DOI: 10.1126/science.1227682
E-Publication Date: November 29, 2012