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The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Sizing Up Cell Growth

cells dividing

Manalis Lab researchers engineered a larger version of their signature microfluidic mass measurement technology to investigate how cell size and cell cycle contribute to cell growth. The study, published in PNAS, reveals that a cell's growth efficiency is primarily determined by its cell cycle state, not its size, and lays the groundwork for using these devices to monitor growth in large cells and 3D clusters with high resolution. The work was supported in part by the Koch Institute Frontier Research Program through the Kathy and Curt Marble Cancer Research Fund and the MIT Center for Cancer Precision Medicine.