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The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

Beyond Cancer Genomics

In an essay for Science Signaling, KI faculty member Michael Yaffe, the David H. Koch Professor of Science, makes a case for looking at cancer not as a disease of genetics, but as a disease of signaling. Yaffe argues that although genetic approaches have resulted in extraordinary insights into the disease, signaling information should be incorporated into the clinical decision-making process. He advocates for improving protein-based measurement technologies to analyze tumor cell signaling in clinical samples. This emphasis on expanding the cancer research focus from genetics to a broader program is echoed by other researchers and initiatives at MIT. For example, at MIT’s Center for Precision Cancer Medicine (which Yaffe directs), researchers explicitly incorporated non-genomic approaches into the fundamental mission and research portfolio. Read more.