The David H. Koch Institute for Integrative Cancer Research at MITThe David H. Koch Institute for Integrative Cancer Research at MIT

Massachusetts Institute of Technology

National Cancer Institute Cancer Center

Science + Engineering... Conquering Cancer Together

In Fighting Shape

Researchers in the laboratories of Scott Manalis and Alex Shalek have teamed up to test whether a cancer cell is fit enough to survive cancer treatment – and identify the weaknesses that may help clinicians knock drug-resistant cells out. The study, appearing in Genome Biology, combines the Shalek Lab's expertise in single-cell mRNA sequencing and a Manalis Lab device that measures the mass and growth rate of individual cells to investigate treatment of glioblastoma in collaboration with Keith Ligon's lab at Dana-Farber Cancer Institute. By overlapping cell measurements from the device and gene expression measurements associated with cellular responses to an experimental drug known as an MDM2 inhibitor, the team identified populations of resistant glioblastoma cells and gained new insights into how to target these cells more efficiently.