Progress: September 2012

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

1.  Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries
Tekin H, Sanchez JG, Landeros C, Dubbin K, Langer R, Khademhosseini A
Publication: Advanced Materials
DOI: 10.1002/adma.201201805
E-Publication Date: September 3, 2012

*2.  Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells
Yamanaka YJ, Berger CT, Sips M, Cheney PC, Alter G, Love JC
Publication: Integrative Biology
DOI: 10.1039/C2IB20167D
E-Publication Date: September 3, 2012

*3.  Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts
Johnson H, Del Rosario AM, Bryson BD, Schroeder MA, Sarkaria JN, White FM
Publication: Molecular and Cellular Proteomics
DOI: 10.1074/mcp.M112.019984
E-Publication Date: September 10, 2012

4.  CD166(pos) Subpopulation From Differentiated Human ES and iPS Cells Support Repair of Acute Lung Injury
Soh BS, Zheng D, Li Yeo JS, Yang HH, Ng SY, Wong LH, Zhang W, Li P, Nichane M, Asmat A, Wong PS, Wong PC, Su LL, Mantalaris SA, Lu J, Xian W, McKeon F, Chen J, Lim EH, Lim B
Publication: Molecular Therapy
DOI: 10.1038/mt.2012.182
E-Publication Date: September 11, 2012

5.  Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer
Agarwal S, Gertler FB, Balsamo M, Condeelis JS, Camp RL, Xue X, Lin J, Rohan TE, Rimm DL
Publication: Breast Cancer Research
DOI: 10.1186/bcr3318
E-Publication Date: September 12, 2012

*6.  Responsive polymeric delivery systems
Kost J, Langer R
Publication: Advanced Drug Delivery Reviews
DOI: 10.1016/j.addr.2012.09.014
E-Publication Date: September 12, 2012

*7.  The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres
Gref R, Domb A, Quellec P, Blunk T, Müller RH, Verbavatz JM, Langer R
Publication: Advanced Drug Delivery Reviews
DOI: 10.1016/j.addr.2012.09.008
E-Publication Date: September 12, 2012

*8.  Transcription of Two Long Noncoding RNAs Mediates Mating-Type Control of Gametogenesis in Budding Yeast
van Werven FJ, Neuert G, Hendrick N, Lardenois A, Buratowski S, van Oudenaarden A, Primig M, Amon A
Publication: Cell
DOI: 10.1016/j.cell.2012.06.049
E-Publication Date: September 14, 2012

9.  M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer Ghosh D, Lee Y, Thomas S, Kohli AG, Yun DS, Belcher AM, Kelly KA
Publication: Nature Nanotechnology
DOI: 10.1038/nnano.2012.146
E-Publication Date: September 16, 2012

*10.  Crosslinked linear polyethylenimine enhances delivery of DNA to the cytoplasm
Bonner DK, Zhao X, Buss H, Langer R, Hammond PT
Publication: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2012.09.004
E-Publication Date: September 17, 2012

*11.  Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks
Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB
Publication: Philosophical Transactions of the Royal Society of London
DOI: 10.1098/rstb.2012.0010
E-Publication Date: September 19, 2012

12.  Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, Delabarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, Qian K, Saunders J, Driggers E, Woo HK, Kunii K, Murray S, Yang H, Yen K, Liu W, Cantley LC, Vander Heiden MG, Su SM, Jin S, Salituro FG, Dang L
Publication: Chemistry and Biology
DOI: 10.1016/j.chembiol.2012.07.021
E-Publication Date: September 21, 2012

13.  Vascular catheters with a nonleaching poly-sulfobetaine surface modification reduce thrombus formation and microbial attachment
Smith RS, Zhang Z, Bouchard M, Li J, Lapp HS, Brotske GR, Lucchino DL, Weaver D, Roth LA, Coury A, Biggerstaff J, Sukavaneshvar S, Langer R, Loose C
Publication: Science Translational Medicine
DOI: 10.1126/scitranslmed.3004120
E-Publication Date: September 26, 2012

14.  Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
Winter GE, Rix U, Carlson SM, Gleixner KV, Grebien F, Gridling M, Müller AC, Breitwieser FP, Bilban M, Colinge J, Valent P, Bennett KL, White FM, Superti-Furga G
Publication: Nature Chemical Biology
DOI: 10.1038/nchembio.1085
E-Publication Date: September 30, 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

*15.  Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI62727
E-Publication Date: September 4, 2012

*16.  Acetate-Bridged Platinum(III) Complexes Derived from Cisplatin
Wilson JJ, Lippard SJ
Publication: Inorganic Chemistry
DOI: 10.1021/ic301289j
E-Publication Date: September 4, 2012

17.  Surface Tethered Epidermal Growth Factor Protects Proliferating and Differentiating Multipotential Stromal Cells from FasL Induced Apoptosis
Rodrigues M, Blair H, Stockdale L, Griffith L, Wells A
Publication: Stem Cells
DOI: 10.1002/stem.1215
E-Publication Date: September 4, 2012

*18.  Measurement and Modeling of Signaling at the Single-Cell Level
Kolitz SE, Lauffenburger DA
Publication: Biochemistry
DOI: 10.1021/bi300846p
E-Publication Date: September 6, 2012

19.  Role of ca(2+) in the control of h(2)o(2)-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes
Sartoretto JL, Kalwa H, Shiroto T, Sartoretto SM, Pluth MD, Lippard SJ, Michel T
Publication: PLoS One
DOI: 10.1371/journal.pone.0044627
E-Publication Date: September 6, 2012

*20.  Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors
Buganim Y, Itskovich E, Hu YC, Cheng AW, Ganz K, Sarkar S, Fu D, Welstead GG, Page DC, Jaenisch R
Publication: Cell Stem Cell
DOI: 10.1016/j.stem.2012.07.019
E-Publication Date: September 7, 2012

21.  Comprehensive genomic characterization of squamous cell lung cancers
The Cancer Genome Atlas Research Network
Publication: Nature
DOI: 10.1038/nature11404
E-Publication Date: September 9, 2012

22.  Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA
Publication: Frontiers in Genetics
DOI: 10.3389/fgene.2012.00177
E-Publication Date: September 11, 2012

*23.  Tiara: a novel catheter-based mitral valve bioprosthesis: initial experiments and short-term pre-clinical results
Banai S, Jolicoeur EM, Schwartz M, Garceau P, Biner S, Tanguay JF, Cartier R, Verheye S, White CJ, Edelman E
Publication: Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2012.05.047
E-Publication Date: September 12, 2012

24.  Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage
Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, Bruneau BG
Publication: Cell
DOI: 10.1016/j.cell.2012.07.035
E-Publication Date: September 12, 2012

25.  Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
Imielinski M, Berger AH, Hammerman PS, Hernandez B, Pugh TJ, Hodis E, Cho J, Suh J, Capelletti M, Sivachenko A, Sougnez C, Auclair D, Lawrence MS, Stojanov P, Cibulskis K, Choi K, de Waal L, Sharifnia T, Brooks A, Greulich H, Banerji S, Zander T, Seidel D, Leenders F, Ansén S, Ludwig C, Engel-Riedel W, Stoelben E, Wolf J, Goparju C, Thompson K, Winckler W, Kwiatkowski D, Johnson BE, Jänne PA, Miller VA, Pao W, Travis WD, Pass HI, Gabriel SB, Lander ES, Thomas RK, Garraway LA, Getz G, Meyerson M
Publication: Cell
DOI: 10.1016/j.cell.2012.08.029
E-Publication Date: September 14, 2012

*26.  Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM
Publication: Cell
DOI: 10.1016/j.cell.2012.07.032
E-Publication Date: September 14, 2012

*27.  Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase
Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, Ganz K, Klemm SL, van Oudenaarden A, Jaenisch R
Publication: Cell
DOI: 10.1016/j.cell.2012.08.023
E-Publication Date: September 14, 2012

*28.  Translational control of protein synthesis: the early years
Lodish HF
Publication: Journal of Biological Chemistry
DOI: 10.1074/jbc.X112.420356
E-Publication Date: September 17, 2012

*29.  Cancer Cell Metabolism: One Hallmark, Many Faces
Cantor JR, Sabatini DM
Publication: Cancer Discovery
DOI: 10.1158/2159-8290.CD-12-0345
E-Publication Date: September 25, 2012

30.  An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity
Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL
Publication: Science Translational Medicine
DOI: 10.1126/scitranslmed.3004186
E-Publication Date: September 26, 2012

*31.  Transcriptional Amplification in Tumor Cells with Elevated c-Myc
Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA
Publication: Cell
DOI: 10.1016/j.cell.2012.08.026
E-Publication Date: September 28, 2012

32.  Receptors and Other Signaling Proteins Required for Serotonin Control of Locomotion in Caenorhabditis elegans
Gürel G, Gustafson MA, Pepper JS, Horvitz HR, Koelle MR
Publication: Genetics
DOI: 10.1534/genetics.112.142125
E-Publication Date: September 28, 2012