Progress: March 2012

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

*1.  Enhanced Stability of Polymeric Micelles Based on Postfunctionalized Poly(ethylene glycol)-b-poly(γ-propargyl l-glutamate): The Substituent Effect
Zhao X, Poon Z, Engler AC, Bonner DK, Hammond PT
Publication: Biomacromolecules
DOI: 10.1021/bm201873u
E-Publication Date: March 1, 2012

2. Photoswitchable nanoparticles for triggered tissue penetration and drug delivery
Tong R, Hemmati HD, Langer R, Kohane DS
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja211888a
E-Publication Date: March 5, 2012

3.  Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP
Publication: Cell
DOI: 10.1021/bm201873u
E-Publication Date: March 6, 2012

4.  Promiscuous binding of extracellular peptides to cell surface class I MHC protein
Eisen HN, Hou XH, Shen C, Wang K, Tanguturi VK, Smith C, Kozyrytska K, Nambiar L, McKinley CA, Chen J, Cohen RJ
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1201586109
E-Publication Date: March 7, 2012

5.  High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry
Andrew L. Hook, David J. Scurr, Daniel G. Anderson, Robert Langer, Paul Williams, Martyn Davies, Morgan Alexander1
Publication: Surface and Interface Analysis
DOI: 10.1002/sia.4910
E-Publication Date: March 8, 2012

*6.  Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery
Nguyen DN, Mahon KP, Chikh G, Kim P, Chung H, Vicari AP, Love KT, Goldberg M, Chen S, Krieg AM, Chen J, Langer R, Anderson DG
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1121423109
E-Publication Date: March 15, 2012

*7.  Therapeutic angiogenesis using genetically engineered human endothelial cells
Cho SW, Yang F, Son SM, Park HJ, Green JJ, Bogatyrev S, Mei Y, Park S, Langer R, Anderson DG
Publication: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2012.03.006
E-Publication Date: March 15, 2012

*8.  Engineering humanized mice for improved hematopoietic reconstitution
Drake AC, Chen Q, Chen J
Publication: Cellular and Molecular Immunology
DOI: 10.1038/cmi.2012.6
E-Publication Date: March 19, 2012

*9.  Evolution: The evolution of metazoan extracellular matrix
Hynes RO
Publication: Journal of Cell Biology
DOI: 10.1083/jcb.201109041
E-Publication Date: March 19, 2012

*10.  Remotely-activated protein-producing nanoparticles
Schroeder A, Goldberg M, Kastrup C, Levins CG, Langer RS, Anderson DG
Publication: Nano Letters
DOI: 10.1021/nl2036047
E-Publication Date: March 20, 2012

*11.  Cationic Peptidopolysaccharides Show Excellent Broad-Spectrum Antimicrobial Activities and High Selectivity
Li P, Zhou C, Rayatpisheh S, Ye K, Poon YF, Hammond PT, Duan H, Chan-Park MB
Publication: Advanced Materials
DOI: 10.1002/adma.201104186
E-Publication Date: March 21, 2012

12.  Development path and current status of the NANIVID: a new device for cancer cell studies
Waseem Khan Raja, Michael R. Padgen, James K. Williams, Frank B. Gertler, Jeffrey B. Wyckoff, John S. Condeelis, James Castracane
Publication: Journal of Micro/Nanolithography, MEMS, and MOEMS
DOI: 10.1117/1.JMM.11.1.013013
E-Publication Date: March 29, 2012

*13.  SnapShot: Lung Cancer Models
Farago AF, Snyder EL, Jacks T
Publication: Cell
DOI: 10.1016/j.cell.2012.03.015
E-Publication Date: March 30, 2012

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

*14.  Slug and Sox9 cooperatively determine the mammary stem cell state
Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Zürrer-Härdi U, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA
Publication: Cell
DOI: 10.1016/j.cell.2012.02.008
E-Publication Date: March 2, 2012

15.  Chromatin-modifying enzymes as modulators of reprogramming
Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ
Publication: Nature
DOI: 10.1038/nature10953
E-Publication Date: March 4, 2012

16.  A critical role for the wnt effector tcf4 in adult intestinal homeostatic self-renewal
van Es JH, Haegebarth A, Kujala P, Itzkovitz S, Koo BK, Boj SF, Korving J, van den Born M, van Oudenaarden A, Robine S, Clevers H
Publication: Molecular and Cellular Biology
DOI: 10.1128/MCB.06288-11
E-Publication Date: March 5, 2012

*17.  CYSL-1 Interacts with the O2-Sensing Hydroxylase EGL-9 to Promote H2S-Modulated Hypoxia-Induced Behavioral Plasticity in C. elegans
Ma DK, Vozdek R, Bhatla N, Horvitz HR
Publication: Neuron
DOI: 10.1016/j.neuron.2011.12.037
E-Publication Date: March 7, 2012

*18.  Ubiquitin-Like Proteins
van der Veen AG, Ploegh HL
Publication: Annual Review of Biochemistry
DOI: 10.1146/annurev-biochem-093010-153308
E-Publication Date: March 9, 2012

19.  Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway
Xu C, Fan ZP, Müller P, Fogley R, Dibiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI
Publication: Developmental Cell
DOI: 10.1016/j.devcel.2012.01.003
E-Publication Date: March 13, 2012

*20.  Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time
Popp MW, Karssemeijer RA, Ploegh HL
Publication: PLoS Pathogens
DOI: 10.1371/journal.ppat.1002604
E-Publication Date: March 22, 2012

*21.  Protein Ligation in Living Cells Using Sortase
Popp MW, Karssemeijer RA, Ploegh HL
Publication: Traffic
DOI: 10.1111/j.1600-0854.2012.01345.x
E-Publication Date: March 23, 2012

22.  A Conserved Cell Growth Cycle Can Account for the Environmental Stress Responses of Divergent Eukaryotes
Slavov N, Airoldi E, van Oudenaarden A, Botstein D
Publication: Molecular Biology of the Cell
DOI: 10.1091/mbc.E11-11-0961
E-Publication Date: March 28, 2012

23.  The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA
Publication: Nature
DOI: 10.1038/nature11003
E-Publication Date: March 28, 2012

24.  The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B
Anderson ES, Lin CH, Xiao X, Stoilov P, Burge CB, Black DL
Publication: RNA
DOI: 10.1261/rna.032912.112
E-Publication Date: March 28, 2012

*25.  Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease
Tardiff DF, Lindquist S
Publication: Drug Discovery Today: Technologies
DOI: 10.1016/j.ddtec.2012.02.003
E-Publication Date: March 29, 2012

26.  Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA
Publication: Science
DOI: 10.1126/science.1215135
E-Publication Date: March 30, 2012