Progress: October 2011

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

1.  The influence of scaffold elasticity on germ layer specification of human embryonic stem cells
Janet Zoldan, Emmanouil D. Karagiannis, Christopher Y. Lee, Daniel G. Anderson, Robert Langer and Shulamit Levenberg
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2011.09.012
E-Publication Date: October 1, 2011

*2.  A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis
Navin Varadarajan, Boris Julg, Yvonne J. Yamanaka, Huabiao Chen, Adebola O. Ogunniyi, Elizabeth McAndrew, Lindsay C. Porter, Alicja Piechocka-Trocha, Brenna J. Hill, Daniel C. Douek, Florencia Pereyra, Bruce D. Walker and J. Christopher Love
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI58653
E-Publication Date: October 3, 2011

*3.  Engineering materials layer-by-layer: Challenges and opportunities in multilayer assembly
Paula T. Hammond
Publication: AIChE Journal
DOI: 10.1002/aic.12769
E-Publication Date: October 3, 2011

4.  Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice
Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ
Publication: Journal of Clinical Investigation
DOI: 10.1172/JCI58675
E-Publication Date: October 3, 2011

5.  Bispecific designed ankyrin repeat proteins (DARPins) targeting the epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling
Ykelien L. Boersma, Ginger Chao, Daniel Steiner, K. Dane Wittrup and Andreas Plückthun
Publication: Journal of Biological Chemistry
DOI: 10.1074/jbc.M111.293266
E-Publication Date: October 6, 2011

*6.  Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release
Neetu Singh, Amrita Karambelkar, Luo Gu, Kevin Lin, Jordan S. Miller, Christopher S. Chen, Michael J. Sailor and Sangeeta N. Bhatia
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja206998x
E-Publication Date: October 7, 2011

7.  PHGDH amplification and altered glucose metabolism in human melanoma
Edouard Mullarky, Katherine R. Mattaini, Matthew G. Vander Heiden, Lewis C. Cantley and Jason W. Locasale
Publication: Pigment Cell and Melanoma Research
DOI: 10.1111/j.1755-148X.2011.00919.x
E-Publication Date: October 8, 2011

8.  Therapeutic siRNA silencing in inflammatory monocytes in mice
Florian Leuschner, Partha Dutta, Rostic Gorbatov, Tatiana I Novobrantseva, Jessica S Donahoe, Gabriel Courties, Kang Mi Lee, James I Kim, James F Markmann, Brett Marinelli, Peter Panizzi, Won Woo Lee, Yoshiko Iwamoto, Stuart Milstein, Hila Epstein-Barash, William Cantley, Jamie Wong, Virna Cortez-Retamozo, Andita Newton, Kevin Love, Peter Libby, Mikael J Pittet, Filip K Swirski, Victor Koteliansky and Robert Langer
Publication: Nature Biotechnology
DOI: 10.1038/nbt.1989
E-Publication Date: October 9, 2011

9.  Chronic activation of wild-type epidermal growth factor receptor and loss of cdkn2a cause mouse glioblastoma formation
Jaime Acquaviva, Hyun Jung Jun, Julie Lessard, Rolando Ruiz, Haihao Zhu, Melissa Donovan, Steve Woolfenden, Abraham Boskovitz, Ami Raval, Roderick T. Bronson, Rolf Pfannl, Charles A. Whittaker, David E. Housman and Al Charest
Publication: Cancer Research
DOI: 10.1158/0008-5472.CAN-11-1514
E-Publication Date: October 10, 2011

*10.  Reshaping the future of nanopharmaceuticals: ad iudicium
Moghimi SM, Peer D, Langer R
Publication: ACS Nano
DOI: 10.1021/nn2038252
E-Publication Date: October 12, 2011

*11.  Layer-by-Layer Assembled Polyaniline Nanofiber/Multiwall Carbon Nanotube Thin Film Electrodes for High-Power and High-Energy Storage Applications
Md Nasim Hyder, Seung Woo Lee, Fevzi Ç. Cebeci, Daniel J. Schmidt, Yang Shao-Horn and Paula T. Hammond
Publication: ACS Nano
DOI: 10.1021/nn2029617
E-Publication Date: October 20, 2011

12.  Fluorescent penetration enhancers for transdermal applications
Seto JE, Polat BE, VanVeller B, Lopez RF, Langer R, Blankschtein D
Publication: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2011.10.018
E-Publication Date: October 21, 2011

13.  Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme
H J Jun, J Acquaviva, D Chi, J Lessard, H Zhu, S Woolfenden, R T Bronson, R Pfannl, F White, D E Housman, L Iyer, C A Whittaker, A Boskovitz, A Raval and A Charest
Publication: Oncogene
DOI: 10.1038/onc.2011.474
E-Publication Date: October 24, 2011

*14.  Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3
Scott M. Carlson, Candace R. Chouinard, Adam Labadorf, Carol J. Lam, Katrin Schmelzle, Ernest Fraenkel and Forest M. White
Publication: Science Signaling
DOI: 10.1126/scisignal.2002010
E-Publication Date: October 25, 2011

*15.  Room Temperature Rapid Photoresponsive Azobenzene Side Chain Liquid Crystal Polymer
Michael Petr and Paula T. Hammond
Publication: Macromolecules
DOI: 10.1021/ma2013173
E-Publication Date: October 25, 2011

*16.  Oligonucleotide Delivery by Cell-Penetrating "Striped" Nanoparticles
Christopher M. Jewell, Jin-Mi Jung, Prabhani U. Atukorale, Randy P. Carney, Francesco Stellacci and Darrell J. Irvine
Publication: Angewandte Chemie (International ed. in English)
DOI: 10.1002/anie.201104514
E-Publication Date: October 26, 2011

*17.  Mass sensors with mechanical traps for weighing single cells in different fluids
Weng Y, Delgado FF, Son S, Burg TP, Wasserman SC, Manalis SR
Publication: Lab on a Chip
DOI: 10.1039/C1LC20736A
E-Publication Date: October 28, 2011

18.  Thermoresponsive Platforms for Tissue Engineering and Regenerative Medicine
Tekin H, Sanchez JG, Tsinman T, Langer R, Khademhosseini A
Publication: AIChE Journal
DOI: 10.1002/aic.12801
E-Publication Date: October 31, 2011

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

19.  Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c
Min Wan, Karla F. Leavens, Danish Saleh, Rachael M. Easton, David A. Guertin, Timothy R. Peterson, Klaus H. Kaestner, David M. Sabatini and Morris J. Birnbaum
Publication: Cell Metabolism
DOI: 10.1016/j.cmet.2011.09.001
E-Publication Date: October 5, 2011

*20.  Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance
J Peter Svensson, Laia Q Pesudo, Rebecca C Fry, Yeyejide A Adeleye, Paul Carmichael and Leona D Samson
Publication: BMC Systems Biology
DOI: 10.1186/1752-0509-5-157
E-Publication Date: October 6, 2011

21.  A high-resolution map of human evolutionary constraint using 29 mammals
Kerstin Lindblad-Toh, Manuel Garber, Or Zuk, Michael F. Lin, Brian J. Parker, Stefan Washietl, Pouya Kheradpour, Jason Ernst, Gregory Jordan, Evan Mauceli, Lucas D. Ward, Craig B. Lowe, Alisha K. Holloway, Michele Clamp, Sante Gnerre, Jessica Alföldi, Kathryn Beal, Jean Chang, Hiram Clawson, James Cuff, Federica Di Palma, Stephen Fitzgerald, Paul Flicek, Mitchell Guttman, Melissa J. Hubisz, David B. Jaffe, Irwin Jungreis, W. James Kent, Dennis Kostka, Marcia Lara, Andre L. Martins, Tim Massingham, Ida Moltke, Brian J. Raney, Matthew D. Rasmussen, Jim Robinson, Alexander Stark, Albert J. Vilella, Jiayu Wen, Xiaohui Xie, Michael C. Zody, Broad Institute Sequencing Platform and Whole Genome Assembly Team, Kim C. Worley, Christie L. Kovar, Donna M. Muzny, Richard A. Gibbs, Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Wesley C. Warren, Elaine R. Mardis, George M. Weinstock, Richard K. Wilson, Genome Institute at Washington University, Ewan Birney, Elliott H. Margulies, Javier Herrero, Eric D. Green, David Haussler, Adam Siepel, Nick Goldman, Katherine S. Pollard, Jakob S. Pedersen, Eric S. Lander and Manolis Kellis
Publication: Nature
DOI: 10.1038/nature10530
E-Publication Date: October 12, 2011

*22.  From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs and chromatin modifications
Shilpa M. Hattangadi, Piu Wong, Lingbo Zhang, Johan Flygare and Harvey F. Lodish
Publication: Blood
DOI: 10.1182/blood-2011-07-356006
E-Publication Date: October 12, 2011

23.  Blimp1 expression predicts embryonic stem cell development in vitro
Li-Fang Chu, M. Azim Surani, Rudolf Jaenisch and Thomas P. Zwaka
Publication: Current Biology
DOI: 10.1016/j.cub.2011.09.010
E-Publication Date: October 13, 2011

*24.  Tumor metastasis: molecular insights and evolving paradigms
Scott Valastyan and Robert A. Weinberg
Publication: Cell
DOI: 10.1016/j.cell.2011.09.024
E-Publication Date: October 14, 2011

*25.  Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression
Qing Gao, Eveline J. Steine, M. Inmaculada Barrasa, Dirk Hockemeyer, Mathias Pawlak, Dongdong Fu, Seshamma Reddy, George W. Bell and Rudolf Jaenisch
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1114946108
E-Publication Date: October 19, 2011

*26.  Functional integration of dopaminergic neurons directly converted from mouse fibroblasts
Jongpil Kim, Susan C. Su, Haoyi Wang, Albert W. Cheng, John P. Cassady, Michael A. Lodato, Christopher J. Lengner, Chee-Yeun Chung, Meelad M. Dawlaty, Li-Huei Tsai and Rudolf Jaenisch
Publication: Cell Stem Cell
DOI: 10.1016/j.stem.2011.09.011
E-Publication Date: October 20, 2011

*27.  Phosphorescent sensor for biological mobile zinc
Youngmin You, Sumin Lee, Taehee Kim, Kei Ohkubo, Weon-Sik Chae, Shunichi Fukuzumi, Gil-Ja Jhon, Wonwoo Nam and Stephen J. Lippard
Publication: Journal of the American Chemical Society
DOI: 10.1021/ja207163r
E-Publication Date: October 24, 2011

*28.  In vivo effects on intron retention and exon skipping by the U2AF large subunit and SF1/BBP in the nematode Caenorhabditis elegans
Long Ma, Zhiping Tan, Yanling Teng, Sebastian Hoersch and H. Robert Horvitz
Publication: RNA
DOI: 10.1261/rna.027458.111
E-Publication Date: October 27, 2011

*29.  Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
Sebastian Treusch, Shusei Hamamichi, Jessica L. Goodman, Kent E. S. Matlack, Chee Yeun Chung, Valeriya Baru, Joshua M. Shulman, Antonio Parrado, Brooke J. Bevis, Julie S. Valastyan, Haesun Han, Malin Lindhagen-Persson, Eric M. Reiman, Denis A. Evans, David A. Bennett, Anders Olofsson, Philip L. DeJager, Rudolph E. Tanzi, Kim A. Caldwell, Guy A. Caldwell, Susan Lindquist
Publication: Science
DOI: 10.1126/science.1213210
E-Publication Date: October 27, 2011

*30.  Generation, translocation, and action of nitric oxide in living systems
Andrew G. Tennyson and Stephen J. Lippard
Publication: Chemistry and Biology
DOI: 10.1016/j.chembiol.2011.09.009
E-Publication Date: October 28, 2011

*31.  Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling
Alan C. Mullen, David A. Orlando, Jamie J. Newman, Jakob Lovén, Roshan M. Kumar, Steve Bilodeau, Jessica Reddy, Matthew G. Guenther, Rodney P. DeKoter and Richard A. Young
Publication: Cell
DOI: 10.1016/j.cell.2011.08.050
E-Publication Date: October 28, 2011

32.  Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration
Eirini Trompouki, Teresa V. Bowman, Lee N. Lawton, Zi Peng Fan, Dai-Chen Wu, Anthony DiBiase, Corey S. Martin, Jennifer N. Cech, Anna K. Sessa, Jocelyn L. Leblanc, Pulin Li, Ellen M. Durand, Christian Mosimann, Garrett C. Heffner, George Q. Daley, Robert F. Paulson, Richard A. Young and Leonard I. Zon
Publication: Cell
DOI: 10.1016/j.cell.2011.09.044
E-Publication Date: October 28, 2011

33.  The thrombospondin repeat containing protein MIG-21 controls a left-right asymmetric Wnt signaling response in migrating C. elegans neuroblasts
Teije C. Middelkoop, Lisa Williams, Pei-Tzu Yang, Jeroen Luchtenberg, Marco C. Betist, Ni Ji, Alexander van Oudenaarden, Cynthia Kenyon and Hendrik C. Korswagen
Publication: Developmental Biology
DOI: 10.1016/j.ydbio.2011.10.029
E-Publication Date: October 29, 2011

34.  High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer
Sandro Santagata, Rong Hu, Nancy U. Lin, Marc L. Mendillo, Laura C. Collins, Susan E. Hankinson, Stuart J. Schnitt, Luke Whitesell, Rulla M. Tamimi, Susan Lindquist and Tan A. Ince
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1115031108
E-Publication Date: October 31, 2011