Progress: September 2011

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Publications Citing Intramural Faculty

*Indicates publications for which a KI intramural faculty member is senior author

*1.  In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles
Christopher M. Jewell, Sandra C. Bustamante López and Darrell J. Irvine
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1105200108
E-Publication Date: September 6, 2011

2.  Liposomes for HIV prophylaxis
Nikita K. Malavia, David Zurakowski, Avi Schroeder, Amy M. Princiotto, Anna R. Laury, Hila E. Barash, Joseph Sodroski, Robert Langer, Navid Madani and Daniel S. Kohane
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2011.07.068
E-Publication Date: September 8, 2011

3.  Nanoparticles Targeting the Infarcted Heart
Tal Dvir, Michael Bauer, Avi Schroeder, Jonathan H. Tsui, Daniel G. Anderson, Robert Langer, Ronglih Liao and Daniel S. Kohane
Publication: Nano Letters
DOI: 10.1021/nl2025882
E-Publication Date: September 7, 2011

*4.  Exploiting bias in a non-immune human antibody library to predict antigenicity
Margaret E. Ackerman, Jennifer I. Lai, Ira Pastan and K. Dane Wittrup
Publication: Protein Engineering, Design and Selection
DOI: 10.1093/protein/gzr046
E-Publication Date: September 9, 2011

*5.  Release of Vancomycin from Multilayer Coated Absorbent Gelatin Sponges
Anita Shukla, Jean C. Fang, Sravanthi Puranam and Paula T. Hammond
Publication: Journal of Controlled Release
DOI: 10.1016/j.jconrel.2011.09.062
E-Publication Date: September 12, 2011

*6.  Genome-wide Impact of a Recently Expanded MicroRNA Cluster in Mouse
Grace X. Y. Zheng, Arvind Ravi, Genevieve M. Gould, Christopher B. Burge and Phillip A. Sharp
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1112772108
E-Publication Date: September 12, 2011

7.  2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase
Martin J. Walsh, Kyle R. Brimacombe, Henrike Veith, James M. Bougie, Thomas Daniel, William Leister, Lewis C. Cantley, William J. Israelsen, Matthew G. Vander Heiden, Min Shen, Douglas S. Auld, Craig J. Thomas and Matthew B. Boxer
Publication: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2011.08.114
E-Publication Date: September 14, 2011

*8.  14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
Alexandra K. Gardino and Michael B. Yaffe
Publication: Seminars in Cell and Developmental Biology
DOI: 10.1016/j.semcdb.2011.09.008
E-Publication Date: September 14, 2011

*9.  Cdc15 Integrates Tem1 GTPase-mediated Spatial Signals with Polo Kinase-mediated Temporal Cues to Activate Mitotic Exit
Jeremy M. Rock and Angelika Amon
Publication: Genes and Development
DOI: 10.1101/gad.17257711
E-Publication Date: September 15, 2011

*10.  Extracellular Matrix Proteins in Hemostasis and Thrombosis
Wolfgang Bergmeier and Richard O. Hynes
Publication: Cold Spring Harbor Perspectives in Biology
DOI: 10.1101/cshperspect.a005132
E-Publication Date: September 21, 2011

11.  Overview of the Matrisome--An Inventory of Extracellular Matrix Constituents and Functions
Richard O. Hynes and Alexandra Naba
Publication: Cold Spring Harbor Perspectives in Biology
DOI: 10.1101/cshperspect.a004903
E-Publication Date: September 21, 2011

12.  Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus
Jessica A. Belser, Akila Jayaraman, Rahul Raman, Claudia Pappas, Hui Zeng, Nancy J. Cox, Jacqueline M. Katz, Ram Sasisekharan, Terrence M. Tumpey
Publication: PLoS One
DOI: 10.1371/journal.pone.0025091
E-Publication Date: September 22, 2011

*13.  Vancomycin Storage Stability in Multilayer Thin Film Coatings for On-Demand Care
Anita Shukla, Sravanthi Puranam and Paula T. Hammond
Publication: Journal of Biomaterials Science, Polymer Edition
E-Publication Date: September 23, 2011

14.  A Disulfide-Free Single-Domain V(L) Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition
André Schiefner, Lorenz Chatwell, Jana Körner, Irmgard Neumaier, David W. Colby, Rudolf Volkmer, K. Dane Wittrup and Arne Skerra
Publication: Journal of Molecular Biology
DOI: 10.1016/j.jmb.2011.09.034
E-Publication Date: September 24, 2011

15.  Islets Transplanted in Immunoisolation Devices: A Review of the Progress and the Challenges that Remain
Esther S. O'Sullivan, Arturo Vegas, Daniel G. Anderson and Gordon C. Weir
Publication: Endocrine Reviews
DOI: 10.1210/er.2010-0026
E-Publication Date: September 27, 2011

16.  The influence of scaffold elasticity on germ layer specification of human embryonic stem cells
Janet Zoldan, Emmanouil D. Karagiannis, Christopher Y. Lee, Daniel G. Anderson, Robert Langer and Shulamit Levenberg
Publication: Biomaterials
DOI: 10.1016/j.biomaterials.2011.09.012
E-Publication Date: September 29, 2011

Publications Citing Extramural Faculty

*Indicates publications for which a KI extramural faculty member is senior author

17.  BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore, Ghayas C. Issa, Madeleine E. Lemieux, Peter B. Rahl, Junwei Shi, Hannah M. Jacobs, Efstathios Kastritis, Timothy Gilpatrick, Ronald M. Paranal, Jun Qi, Marta Chesi, Anna C. Schinzel, Michael R. McKeown, Timothy P. Heffernan, Christopher R. Vakoc, P. Leif Bergsagel, Irene M. Ghobrial, Paul G. Richardson, Richard A. Young, William C. Hahn, Kenneth C. Anderson, Andrew L. Kung, James E. Bradner and Constantine S. Mitsiades
Publication: Cell
DOI: 10.1016/j.cell.2011.08.017
E-Publication Date: September 1, 2011

18.  Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding
Laura B. Kleiman, Thomas Maiwald, Holger Conzelmann, Douglas A. Lauffenburger and Peter K. Sorger
Publication: Molecular Cell
DOI: 10.1016/j.molcel.2011.07.014
E-Publication Date: September 2, 2011

19.  Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage
Wen-Hui Lien, Xingyi Guo, Lisa Polak, Lee N. Lawton, Richard A. Young, Deyou Zheng and Elaine Fuchs
Publication: Cell Stem Cell
DOI: 10.1016/j.stem.2011.07.015
E-Publication Date: September 2, 2011

20.  Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion
Adam J Bass, Michael S Lawrence, Lear E Brace, Alex H Ramos, Yotam Drier, Kristian Cibulskis, Carrie Sougnez, Douglas Voet, Gordon Saksena, Andrey Sivachenko, Rui Jing, Melissa Parkin, Trevor Pugh, Roel G Verhaak, Nicolas Stransky, Adam T Boutin, Jordi Barretina, David B Solit, Evi Vakiani, Wenlin Shao, Yuji Mishina, Markus Warmuth, Jose Jimenez, Derek Y Chiang, Sabina Signoretti, William G Kaelin, Nicole Spardy, William C Hahn, Yujin Hoshida, Shuji Ogino, Ronald A DePinho, Lynda Chin, Levi A Garraway, Charles S Fuchs, Jose Baselga, Josep Tabernero, Stacey Gabriel, Eric S Lander, Gad Getz and Matthew Meyerson
Publication: Nature Genetics
DOI: 10.1038/ng.936
E-Publication Date: September 4, 2011

*21.  Characterization of a synthetic peroxodiiron(iii) protein model complex by nuclear resonance vibrational spectroscopy
Loi H. Do,  Hongxin Wang,  Christine E. Tinberg,  Eric Dowty,  Yoshitaka Yoda,  Stephen P. Cramer and Stephen J. Lippard
Publication: Chemical Communications (Cambridge, England)
DOI: 10.1039/c1cc13836g
E-Publication Date: September 6, 2011

*22.  Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9
Ana M. Avalos and Hidde L. Ploegh
Publication: European Journal of Immunology
DOI: 10.1002/eji.201141563
E-Publication Date: September 6, 2011

*23.  Seminaphthofluorescein-Based Fluorescent Probes for Imaging Nitric Oxide in Live Cells
Michael D. Pluth, Maria R. Chan, Lindsey E. McQuade and Stephen J. Lippard
Publication: Inorganic Chemistry
DOI: 10.1021/ic200986v
E-Publication Date: September 7, 2011

24.  Chemical and Biological Approaches for Adapting Proteostasis to Ameliorate Protein Misfolding and Aggregation Diseases-Progress and Prognosis
Susan L. Lindquist and Jeffery W. Kelly
Publication: Cold Spring Harbor Perspectives in Biology
DOI: 10.1101/cshperspect.a004507
E-Publication Date: September 7, 2011

25.  Determinants of GBP Recruitment to Toxoplasma gondii Vacuoles and the Parasitic Factors That Control It
Sebastian Virreira Winter, Wendy Niedelman, Kirk D. Jensen, Emily E. Rosowski, Lindsay Julien, Eric Spooner, Kacey Caradonna, Barbara A. Burleigh, Jeroen P. J. Saeij, Hidde L. Ploegh and Eva-Maria Frickel
Publication: PLoS One
DOI: 10.1371/journal.pone.0024434
E-Publication Date: September 8, 2011

26.  The Msx1 Homeoprotein Recruits Polycomb to the Nuclear Periphery during Development
Jingqiang Wang, Roshan M. Kumar, Vanessa J. Biggs, Hansol Lee, Yun Chen, Michael H. Kagey, Richard A. Young and Cory Abate-Shen
Publication: Developmental Cell
DOI: 10.1016/j.devcel.2011.07.003
E-Publication Date: September 13, 2011

*27.  MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans
David T. Harris and H. Robert Horvitz
Publication: Development
DOI: 10.1242/dev.065417
E-Publication Date: September 15, 2011

28.  Conserved Regulation of p53 Network Dosage by MicroRNA-125b Occurs through Evolving miRNA-Target Gene Pairs
Minh T. N. Le, Ng Shyh-Chang, Swea Ling Khaw, Lingzi Chin, Cathleen Teh, Junliang Tay, Elizabeth O'Day, Vladimir Korzh, Henry Yang, Ashish Lal, Judy Lieberman, Harvey F. Lodish and Bing Lim
Publication: PLoS Genetics
DOI: 10.1371/journal.pgen.1002242
E-Publication Date: September 15, 2011

29.  Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis
Juliano L. Sartoretto, Hermann Kalwa, Michael D. Pluth, Stephen J. Lippard and Thomas Michel
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1111331108
E-Publication Date: September 20, 2011

*30.  Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins
Jane C. Kim and Terry L. Orr-Weaver
Publication: Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1114209108
E-Publication Date: September 20, 2011

*31.  Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes
Mohan Viswanathan and Leonard Guarente
Publication: Nature
DOI: 10.1038/nature10440
E-Publication Date: September 21, 2011

32.  Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse
Enhui Pan, Xiao-an Zhang, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, Stephen J. Lippard and James O. McNamara
Publication: Neuron
DOI: 10.1016/j.neuron.2011.07.019
E-Publication Date: September 21, 2011

33.  Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors
Tamara Major, Jayanthi Menon, Gordon Auyeung, Frank Soldner, Dirk Hockemeyer, Rudolf Jaenisch and Viviane Tabar
Publication: PLoS One
DOI: 10.1371/journal.pone.0024687
E-Publication Date: September 22, 2011

*34.  Metabolic signals regulate SIRT1 expression
Angeliki Chalkiadaki and Leonard Guarente
Publication: EMBO Reports
DOI: 10.1038/embor.2011.179
E-Publication Date: September 23, 2011